Serpin A1a 蛋白, Mouse (HEK293, His)

Alpha-1 protease inhibitor 1 Protein, Mouse (HEK293, His) is a mouse recombinant Serpin A1a with a His tag at the C-terminus. Alpha-1 protease inhibitor 1 Protein, Mouse (HEK293, His) is produced by Mammalian expression system and the target gene encoding Glu25-Lys413 is expressed.

Alpha-1-抗胰蛋白酶 1-1（Serpin A1a；AAT）是最丰富的循环丝氨酸蛋白酶抑制剂（serpin），也是丝氨酸蛋白酶抑制剂超家族的原型成员。52 kD Serpin A1a 蛋白由基因 SERPINA1 编码。Serpin A1a 在调节免疫、炎症、蛋白质稳态、细胞凋亡以及可能的细胞衰老程序中发挥着重要作用。由于基因突变而导致的 Serpin A1a 系统性缺陷可导致肝衰竭和肺气肿等慢性肺部疾病^[1]。

Mouse

HEK293

C-6*His

P07758 (E25-K413)

20700  [NCBI]

EDVQETDTSQKDQSPASHEIATNLGDFAISLYRELVHQSNTSNIFFSPVSIATAFAMLSLGSKGDTHTQILEGLQFNLTQTSEADIHKSFQHLLQTLNRPDSELQLSTGNGLFVNNDLKLVEKFLEEAKNHYQAEVFSVNFAESEEAKKVINDFVEKGTQGKIAEAVKKLDQDTVFALANYILFKGKWKKPFDPENTEEAEFHVDESTTVKVPMMTLSGMLHVHHCSTLSSWVLLMDYAGNATAVFLLPDDGKMQHLEQTLSKELISKFLLNRRRRLAQIHFPRLSISGEYNLKTLMSPLGITRIFNNGADLSGITEENAPLKLSQAVHKAVLTIDETGTEAAAVTVLQMVPMSMPPILRFDHPFLFIIFEEHTQSPIFLGKVVDPTHKHHHHHH

52-65 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filter solution of 20 mM Tris, 150 mM NaCl, pH 8.0.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.

• [1]. Hunt JM, et al. Alpha 1 anti-trypsin: one protein, many functions. Curr Mol Med. 2012 Aug;12(7):827-35.  [Content Brief]