Animal-Free FGF-6 蛋白, Human (His)

The FGF-6 protein coordinates cell proliferation, differentiation, angiogenesis, and myogenesis and is critical for normal muscle regeneration. It interacts with FGFR1, FGFR2, and FGFR4 to mediate signaling cascades that affect various cellular processes. Animal-Free FGF-6 Protein, Human (His) is the recombinant human-derived animal-FreeFGF-6 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free FGF-6 Protein, Human (His) is 168 a.a., with molecular weight of ~19.66 kDa.

FGF-6 蛋白在协调细胞增殖、分化、血管生成和肌肉生成的复杂调节中发挥着关键作用，同时在确保正常的肌肉再生中发挥着至关重要的作用。它与 FGFR1、FGFR2 和 FGFR4 的相互作用强调了它参与介导影响各种细胞过程的信号级联反应。此外，硫酸乙酰肝素糖胺聚糖的存在增强了成纤维细胞生长因子 (FGF) 与其受体之间的亲和力，在这个复杂的信号网络中充当辅助受体。FGF-6 蛋白的多方面作用强调了其在协调重要细胞事件中的重要性，强调了其在组织发育、血管生成和肌肉再生的复杂过程中的作用。

Measure by its ability to induce 3T3 cells proliferation. The ED₅₀ for this effect is <0.1 ng/mL. The specific activity of recombinant human FGF-6 is >1 x 10⁷IU/mg.

Human

E. coli

C-His

P10767 (G41-I208)

2251  [NCBI]

MGTRANNTLLDSRGWGTLLSRSRAGLAGEIAGVNWESGYLVGIKRQRRLYCNVGIGFHLQVLPDGRISGTHEENPYSLLEISTVERGVVSLFGVRSALFVAMNSKGRLYATPSFQEECKFRETLLPNNYNAYESDLYQGTYIALSKYGRVKRGSKVSPIMTVTHFLPRI

Approximately 19.66 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a solution containing 20 mM sodium citrate, 0.2 M NaCl, pH 3.5, trehalose.

<0.1 EU per 1 μg of the protein by the LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.