Annexin A13/ANXA13 蛋白, Human

Annexin A13 Protein, Human is a 35-kDa multifunctional protein which belongs to the annexin family. Annexin A13 is highly expressed in the digestive system and may plays a role in apoptotic cell-mediated immunosuppression, hypertension, and cell death recognition. Annexin A13 can be used as biomarker in CRC biomarker in colorectal cancer (CRC)^[1].

膜联蛋白由一个蛋白质家族组成，涉及细胞膜动力学和膜相关蛋白调节的许多方面。
ANX A13 是一种钙依赖性磷脂结合蛋白，优先位于细胞膜的胞质面上。质膜。膜联蛋白 A13 在细胞骨架相互作用、磷脂酶抑制、细胞生长调节和细胞内信号转导途径中发挥重要作用。
人膜联蛋白 A13 与小鼠和狗膜联蛋白 A13 的氨基酸序列一致性约为 86% 和 91%。

Human

E. coli

Tag Free

P27216 (G2-H316)

312  [NCBI]

GNRHAKASSPQGFDVDRDAKKLNKACKGMGTNEAAIIEILSGRTSDERQQIKQKYKATYGKELEEVLKSELSGNFEKTALALLDRPSEYAARQLQKAMKGLGTDESVLIEVLCTRTNKEIIAIKEAYQRLFDRSLESDVKGDTSGNLKKILVSLLQANRNEGDDVDKDLAGQDAKDLYDAGEGRWGTDELAFNEVLAKRSYKQLRATFQAYQILIGKDIEEAIEEETSGDLQKAYLTLVRCAQDCEDYFAERLYKSMKGAGTDEETLIRIVVTRAEVDLQGIKAKFQEKYQKSLSDMVRSDTSGDFRKLLVALLH

Approximately 33.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filter solution of 20 mM Tris-HCl, 100 mM NaCl, 10% Glycerol, pH 8.0.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.

• [1]. Guozhong Jiang, et al. Annexin A13 promotes tumor cell invasion in vitro and is associated with metastasis in human colorectal cancer. Oncotarget. 2017 Mar 28;8(13):21663-21673.  [Content Brief]

  [2]. Volker Gerke, et al. Annexins: from structure to function.Physiol Rev. 2002 Apr;82(2):331-71.  [Content Brief]