AQP4 蛋白, Human (His-SUMO)

The AQP4 protein forms water-specific channels and is involved in brain water balance and solute transport. AQP4 Protein, Human (His-SUMO) is the recombinant human-derived AQP4 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of AQP4 Protein, Human (His-SUMO) is 71 a.a., with molecular weight of ~27 kDa.

AQP4 是一种水特异性通道，有助于维持脑水稳态和促进类淋巴溶质运输。它在调节血脑界面的水交换、影响脑脊液通过穿通动脉周围的血管旁间隙流入大脑皮层和实质中起着至关重要的作用。此外，AQP4 对于沿静脉旁通路正确排出间质液至关重要，有助于从脑间质液中正常清除溶质，包括源自 APP 的可溶性 β-淀粉样肽。虽然在尿水稳态和浓缩能力方面是多余的，但 AQP4 形成同源四聚体，其中四聚体能够在膜中组织成不同尺寸的寡聚阵列。这种寡聚化可以通过相邻细胞中 AQP4 阵列之间的相互作用促进细胞与细胞的粘附。AQP4 也是涉及 MLC1、TRPV4、HEPACAM 和 ATP1B1 的复合体的一部分，突出了其在更大的分子网络中的作用。

Human

E. coli

N-6*His;N-SUMO

P55087 (C253-V323)

361  [NCBI]

CPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVHVIDVDRGEEKKGKDQSGEVLSSV

Approximately 27 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm solution of PBS, 6% Trehalose, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.