Arginase-2/ARG2 蛋白, Mouse (His-SUMO)

Arginase-2 (ARG2) is a multifunctional regulator central to the regulation of arginine metabolism and nitric oxide synthesis outside the urea cycle. In addition to its hepatic effects, ARG2 affects innate and adaptive immune responses, negatively affecting the survival of activated CD4(+) and CD8(+) T cells. Arginase-2/ARG2 Protein, Mouse (His-SUMO) is the recombinant mouse-derived Arginase-2/ARG2 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of Arginase-2/ARG2 Protein, Mouse (His-SUMO) is 332 a.a., with molecular weight of ~52.4 kDa.

精氨酸酶-2 (ARG2) 在细胞调节中发挥着多方面的作用，在协调尿素循环外精氨酸代谢和调节一氧化氮合成方面发挥着关键作用。除了其肝功能之外，ARG2 的影响还延伸到先天性和适应性免疫反应，这表明 ARG2 在塑造免疫景观中发挥着关键作用。值得注意的是，它似乎对活化的 CD4+ 和 CD8+ T 细胞的生存能力产生负调节，对哮喘气道上皮炎症相关信号传导产生影响。幽门螺杆菌的免疫逃避策略也可能涉及ARG2，限制M1巨噬细胞的激活和多胺代谢。此外，ARG2 有助于产前免疫抑制并调节 RPS6KB1 信号传导，影响内皮细胞衰老和炎症。有趣的是，ARG2 的作用延伸至内皮自噬和血管平滑肌细胞衰老和凋亡，强调了其独立于其经典酶活性的多种功能。

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Mouse

E. coli

N-6*His;N-SUMO

O08691 (V23-I354)

11847  [NCBI]

VHSVAIVGAPFSRGQKKLGVEYGPAAIREAGLLKRLSRLGCHLKDFGDLSFTNVPQDDPYNNLVVYPRSVGLANQELAEVVSRAVSGGYSCVTMGGDHSLAIGTIIGHARHRPDLCVIWVDAHADINTPLTTVSGNIHGQPLSFLIKELQDKVPQLPGFSWIKPCLSPPNIVYIGLRDVEPPEHFILKNYDIQYFSMREIDRLGIQKVMEQTFDRLIGKRQRPIHLSFDIDAFDPKLAPATGTPVVGGLTYREGVYITEEIHNTGLLSALDLVEVNPHLATSEEEAKATARLAVDVIASSFGQTREGGHIVYDHLPTPSSPHESENEECVRI

Approximately 52.4 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm sterile filtered PBS, 6% Trehalose, pH 7.4

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.