Casein Kinase I gamma-2 蛋白, Human (His)

Casein kinase I gamma-2 Protein, Human (His) is an approximately 55.0 kDa human casein kinase I isoform gamma-2 protein with a His-flag expressed in E. coli. Human Casein kinase I isoform gamma-2 may exhibit overexpression during tumorigenesis and belongs to the CKI family^[1].

酪蛋白激酶 I gamma 2 同种型 (CSNK1G2) 是酪蛋白激酶 I (CKI) 亚家族的成员。丝氨酸/苏氨酸激酶的酪蛋白激酶 I (CKI) 家族在多种真核生物中普遍表达，包括酵母和人类以及植物。
该激酶家族还包括其他亚型（α、β、γ）和德尔塔）。除γ亚型外，两种CKI亚型均可增加体内Dsh的磷酸化。
CSNK1G2在人类癌症中过度表达，它可能在肿瘤发生过程中充当癌蛋白。CSNK1G2 在肿瘤发生过程中可以充当癌蛋白。此外，我们发现CKI-γ2可以以抗雌激素依赖性方式磷酸化MTA1，但不能磷酸化ER

Human

E. coli

N-6*His

P78368 (F92-K415)

1455  [NCBI]

HHHHHHMSKAGGGRSSHGIRSSGTSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLSATEGVPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRSGFVFDYEYDWAGKPLPTPIGTVHTDLPSQPQLRDKTQPHSKNQALNSTNGELNADDPTAGHSNAPITAPAEVEVADETKCCCFFKRRKRKSLQRHK

Approximately 55.0 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.

• [1]. R M McKay, et al. The casein kinase I family in Wnt signaling. Dev Biol. 2001 Jul 15;235(2):388-96.  [Content Brief]

  [2]. Sandip K Mishra, et al. Metastatic tumor antigen 1 short form (MTA1s) associates with casein kinase I-gamma2, an estrogen-responsive kinase. Oncogene. 2004 May 27;23(25):4422-9.  [Content Brief]