CD204/MSR1 蛋白, Human (HEK293, His)

The CD204/MSR1 protein encoded by this gene consists of three isoforms. These integral membrane glycoproteins are mainly expressed in macrophages and play important roles in processes such as atherosclerosis and Alzheimer's disease. CD204/MSR1 Protein, Human (HEK293, His) is the recombinant human-derived CD204/MSR1 protein, expressed by HEK293 , with N-6*His labeled tag. The total length of CD204/MSR1 Protein, Human (HEK293, His) is 375 a.a., with molecular weight of 55-75 kDa.

该基因编码的 CD204/MSR1 蛋白是一种 A 类巨噬细胞清道夫受体，包含由可变剪接产生的三种不同亚型（1 型、2 型和 3 型）。这些三聚体整合膜糖蛋白主要在巨噬细胞中表达，在各种巨噬细胞相关的生理和病理过程中发挥着至关重要的作用，例如动脉粥样硬化、阿尔茨海默病和宿主防御。1 型和 2 型亚型均充当能够内化修饰的低密度脂蛋白 (LDL) 的受体。相比之下，3 型亚型尽管具有负责介导内吞作用的结构域，但由于细胞内加工和内质网内保留的改变而无法内化修饰的 LDL。有趣的是，当共表达时，3 型同工型可以抑制 1 型和 2 型同工型的功能，表明显性负效应，并暗示了调节巨噬细胞清道夫受体活性的机制。此外，该蛋白在多种组织中广泛表达，包括肺和胆囊以及 19 种其他组织。

Data is not available.

Human

HEK293

N-6*His

NP_619729.1 (K77-L451)

4481  [NCBI]

KWETKNCSVSSTNANDITQSLTGKGNDSEEEMRFQEVFMEHMSNMEKRIQHILDMEANLMDTEHFQNFSMTTDQRFNDILLQLSTLFSSVQGHGNAIDEISKSLISLNTTLLDLQLNIENLNGKIQENTFKQQEEISKLEERVYNVSAEIMAMKEEQVHLEQEIKGEVKVLNNITNDLRLKDWEHSQTLRNITLIQGPPGPPGEKGDRGPTGESGPRGFPGPIGPPGLKGDRGAIGFPGSRGLPGYAGRPGNSGPKGQKGEKGSGNTLTPFTKVRLVGGSGPHEGRVEILHSGQWGTICDDRWEVRVGQVVCRSLGYPGVQAVHKAAHFGQGTGPIWLNEVFCFGRESSIEECKIRQWGTRACSHSEDAGVTCTL

55-75 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.