CD24 蛋白, Rat (HEK293, Fc)

The CD24 protein plays a critical role in cellular differentiation in various cell types, possibly triggered by binding of lectin-like ligands to the CD24 carbohydrate. This signal is transduced through second messengers released from GPI anchors. CD24 Protein, Rat (HEK293, Fc) is the recombinant rat-derived CD24 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD24 Protein, Rat (HEK293, Fc) is 29 a.a., with molecular weight of 45-57 kDa.

CD24 蛋白似乎在各种细胞类型的细胞分化中发挥着关键作用，其信号传导可能是由凝集素样配体与 CD24 碳水化合物的结合引发的。该信号通过 GPI 锚释放的第二信使进行转导。此外，CD24 参与调节 B 细胞激活反应，并与 SIGLEC10 结合，可能有助于选择性抑制对危险相关分子模式 (DAMP)（如 HMGB1、HSP70 和 HSP90）的免疫反应。这些发现表明 CD24 具有多方面的作用，包括其对细胞分化、免疫反应调节的影响以及对控制自身免疫的潜在贡献。进一步探索这些功能背后的具体机制可以为 CD24 在细胞过程中发挥的不同作用提供有价值的见解。

When Recombinant Rat CD24 Protein is immobilized at 2 µg/mL (100 µL/well) can bind Anti-CD24 antibody, The ED₅₀ for this effect is 2.235 µg/mL.

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  When Recombinant Rat CD24 Protein is immobilized at 2 µg/mL (100 µL/well) can bind Anti-CD24 antibody, The ED₅₀ for this effect is 2.235 µg/mL.

Rat

HEK293

C-hFc

Q07490 (N27-C55)

25145  [NCBI]

NQTSVAPFSGNQSISAAPNPTNATTRSGC

Approximately 45-57 kDa due to the glycosylation.

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.