CDK2AP2 蛋白, Human (HEK293, His)

CDK2AP2 protein, a vital component of the NuRD complex, actively engages in chromatin remodeling. It inhibits G1/S phase transition by suppressing CDK2, impeding CDK2's interaction with cyclin E or A. Beyond cell cycle control, CDK2AP2 is crucial for ESC self-renewal, ensuring survival during differentiation, and regulates microtubule organization in metaphase II oocytes. Part of the NuRD complex, CDK2AP2 collaborates with proteins like MTA1, MTA2, HDAC1, and others, showcasing its multifaceted regulatory functions. CDK2AP2 Protein, Human (HEK293, His) is the recombinant human-derived CDK2AP2 protein, expressed by HEK293, with C-6*His labeled tag. The total length of CDK2AP2 Protein, Human (HEK293, His) is 126 a.a., with molecular weight of ~26.0 kDa.

CDK2AP2 蛋白作为组蛋白脱乙酰酶 NuRD 复合物的关键组成部分，积极参与染色质重塑。其调节作用延伸至通过抑制 CDK2 表达和激活来抑制细胞周期中的 G1/S 相变，这是通过干扰 CDK2 与细胞周期蛋白 E 或 A 之间的相互作用来实现的。除了细胞周期控制之外，CDK2AP2 在自身细胞周期中发挥着至关重要的作用。-胚胎干细胞（ESC）的更新并确保ESC终末分化期间细胞的存活。此外，它还有助于调节中期 II 卵母细胞的微管组织。作为 NuRD 阻遏蛋白复合体的一部分，CDK2AP2 与各种核心和外周相关蛋白合作，包括 MTA1、MTA2、MTA3、RBBP4、RBBP7、HDAC1、HDAC2、MBD2、MBD3、CDK2AP1、GATAD2A、GATAD2B、CHD3、CHD4 和 CHD5。与 CDK2AP1、CDK2 和 MAPK1 的相互作用进一步强调了其多方面的调节功能。

Human

HEK293

C-6*His

O75956 (M1-T126)

10263  [NCBI]

MSYKPIAPAPSSTPGSSTPGPGTPVPTGSVPSPSGSVPGAGAPFRPLFNDFGPPSMGYVQAMKPPGAQGSQSTYTDLLSVIEEMGKEIRPTYAGSKSAMERLKRGIIHARALVRECLAETERNART

Approximately 26.0 kDa

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.