CLIC5 蛋白, Human (His)

The CLIC5 protein is essential for normal hearing and contributes to the formation of stereocilia and the development of the organ of Corti in the inner ear. It forms poorly selective ion channels that may transport chloride ions. CLIC5 Protein, Human (His) is the recombinant human-derived CLIC5 protein, expressed by E. coli , with N-6*His labeled tag.

CLIC5 蛋白对于正常听力至关重要，因为它对于内耳静纤毛的形成和柯蒂氏器的正常发育是必需的。它能够插入膜并形成选择性较差的离子通道，可能传输氯离子。此外，CLIC5可能在调节上皮细胞离子的吸收和分泌中发挥作用。它对于肾脏中肾小球内皮细胞和足细胞的适当结构的发育和维持也至关重要。此外，CLIC5 有助于眼睛中晶状体缝合线的形成，这对于维持晶状体的光学特性至关重要。它是包含多种细胞骨架蛋白（包括肌动蛋白、埃兹蛋白、α-肌动蛋白、凝溶胶蛋白和 IQGAP1）的复合物的组成部分，并与 AKAP9 相互作用。

Human

E. coli

N-6*His

Q9NZA1-2 (M1-S251)

53405  [NCBI]

MTDSATANGDDRDPEIELFVKAGIDGESIGNCPFSQRLFMILWLKGVVFNVTTVDLKRKPADLHNLAPGTHPPFLTFNGDVKTDVNKIEEFLEETLTPEKYPKLAAKHRESNTAGIDIFSKFSAYIKNTKQQNNAALERGLTKALKKLDDYLNTPLPEEIDANTCGEDKGSRRKFLDGDELTLADCNLLPKLHVVKIVAKKYRNYDIPAEMTGLWRYLKNAYARDEFTNTCAADSEIELAYADVAKRLSRS

Approximately 32.0 kDa

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.