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  3. CREG1/CREG 蛋白, Human (HEK293, His)

CREG1/CREG 蛋白, Human (HEK293, His)

目录号: HY-P7849
产品使用指南

CREG1/CREG蛋白可能有助于细胞生长和分化的转录控制,并在抵抗腺病毒E1A蛋白诱导的细胞转化中发挥关键作用。其活性取决于与 IGF2R 的相互作用,作为糖基化依赖性同二聚体发挥作用。CREG1/CREG 蛋白, Human (HEK293, His) 是重组的 CREG1/CREG 蛋白,由 HEK293 表达,带有 C-6*His 标签。CREG1/CREG 蛋白, Human (HEK293, His) 全长 189 个氨基酸,分子量为 20-38 kDa。

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描述

CREG1/CREG proteins may contribute to the transcriptional control of cell growth and differentiation and play a key role in counteracting cellular transformation induced by the adenovirus E1A protein. Its activity depends on interaction with IGF2R, functioning as a glycosylation-dependent homodimer. CREG1/CREG Protein, Human (HEK293, His) is the recombinant human-derived CREG1/CREG protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CREG1/CREG Protein, Human (HEK293, His) is 189 a.a., with molecular weight of 20-38 kDa.

研究背景

CREG1/CREG 蛋白作为细胞生长和分化的转录控制的潜在贡献者出现。它在拮抗转录激活和对抗腺病毒 E1A 蛋白诱导的细胞转化方面发挥着关键作用。此外,与细胞生长相关的转录控制活性取决于CREG1/CREG和IGF2R之间的相互作用。作为同二聚体,CREG1/CREG 还表现出与 IGF2R 的相互作用,这种相互作用是糖基化依赖性的。这些发现表明 CREG1/CREG 在调节细胞过程中发挥多方面的作用,揭示了其参与转录控制机制及其与 IGF2R 等关键细胞成分的相互作用。对这些相互作用的更深入探索可能会为控制细胞生长和分化的微妙分子机制提供有价值的见解。

种属

Human

表达系统

HEK293

标签

C-6*His

蛋白编号

O75629 (R32-Q220)

基因 ID
蛋白结构
N-term
CREG1 (R32-Q220)
Accession # O75629
6*His
C-term
同用名
rHuProtein CREG1/CREG, His; CREG1; cellular repressor of E1A-stimulated genes; cellular repressor of E1A-stimulated genes 1CREG; protein CREG1
氨基酸序列

RGGRDHGDWDEASRLPPLPPREDAARVARFVTHVSDWGALATISTLEAVRGRPFADVLSLSDGPPGAGSGVPYFYLSPLQLSVSNLQENPYATLTMTLAQTNFCKKHGFDPQSPLCVHIMLSGTVTKVNETEMDIAKHSLFIRHPEMKTWPSSHNWFFAKLNITNIWVLDYFGGPKIVTPEEYYNVTVQ

分子量

20-38 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

CREG1/CREG Protein, Human (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
CREG1/CREG Protein, Human (HEK293, His)
目录号:
HY-P7849
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