CSNK1E 蛋白, Human (P. pastoris, His)

CSNK1E, a member of the casein kinase family, is characterized by its preferential phosphorylation of acidic proteins, particularly caseins. The protein plays a pivotal role in Wnt signaling, as evidenced by its phosphorylation of DVL1 and DVL2, contributing to the intricate regulation of this pathway. Beyond its involvement in Wnt signaling, CSNK1E serves as a central component of the circadian clock, influencing the circadian period length by orchestrating the speed and rhythmicity of PER1 and PER2 phosphorylation. Acting in equilibrium with PP1, it governs the nuclear transport and degradation of PER1 and PER2, thereby intricately regulating the circadian rhythm. Additionally, CSNK1E demonstrates its regulatory influence by inhibiting cytokine-induced granulocytic differentiation, further emphasizing its multifaceted roles in cellular processes. CSNK1E Protein, Human (P. pastoris, His) is the recombinant human-derived CSNK1E protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of CSNK1E Protein, Human (P. pastoris, His) is 416 a.a., with molecular weight of 49.3 kDa.

CSNK1E 是酪蛋白激酶家族的成员，其特点是优先磷酸化酸性蛋白，特别是酪蛋白。该蛋白在 Wnt 信号传导中发挥着关键作用，其 DVL1 和 DVL2 磷酸化就证明了这一点，有助于对该通路的复杂调节。除了参与 Wnt 信号传导之外，CSNK1E 还作为生物钟的核心组成部分，通过协调 PER1 和 PER2 磷酸化的速度和节律来影响昼夜节律的长度。它与 PP1 平衡作用，控制 PER1 和 PER2 的核运输和降解，从而复杂地调节昼夜节律。此外，CSNK1E 通过抑制细胞因子诱导的粒细胞分化发挥调节作用，进一步强调其在细胞过程中的多方面作用。

Human

P. pastoris

N-6*His

P49674 (M1-K416)

102800317  [NCBI]

MELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQGGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGAARNPEDVDRERREHEREERMGQLRGSATRALPPGPPTGATANRLRSAAEPVASTPASRIQPAGNTSPRAISRVDRERKVSMRLHRGAPANVSSSDLTGRQEVSRIPASQTSVPFDHLGK

49.3 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.