CSNK2A2 蛋白, Human (His-SUMO)

CSNK2A2 is the catalytic subunit of the serine/threonine protein kinase complex. It regulates important processes such as cell cycle, apoptosis, and transcription, and affects viral infection. During mitosis, CSNK2A2 maintains CDK1 activity and induces cell cycle arrest. In addition, CSNK2A2 phosphorylates p53/TP53 and negatively regulates apoptosis. It widely affects cell signaling, phosphorylated caspases, the apoptotic factor NOL3, and RNA polymerase, among others. CSNK2A2 also regulates Wnt signaling and acts as a kinase for extracellular proteins. CSNK2A2 Protein, Human (His-SUMO) is the recombinant human-derived CSNK2A2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of CSNK2A2 Protein, Human (His-SUMO) is 343 a.a., with molecular weight of 56.7 kDa.

CSNK2A2 蛋白的催化亚基作为组成型活性丝氨酸/苏氨酸蛋白激酶复合物的核心成分发挥作用，对磷酸化丝氨酸或苏氨酸 C 端酸性残基表现出广泛的底物特异性。CSNK2A2 作为调节节点，在多种细胞过程中发挥着关键作用，包括细胞周期进程、细胞凋亡、转录和病毒感染。它有助于有丝分裂期间 p53/TP53 依赖性纺锤体组装检查点，维持细胞周期蛋白-B-CDK1 活性和响应纺锤体损伤的 G2 停滞。此外，CSNK2A2 还参与细胞凋亡调节，磷酸化半胱天冬酶和 NOL3 等关键参与者。其影响延伸至转录调控，通过 RNA 聚合酶和众多转录因子的直接磷酸化。在复杂的细胞信号传导过程中，CSNK2A2 参与 Wnt 信号传导，充当细胞外蛋白的胞外激酶，并使参与不同病毒生命周期的各种蛋白磷酸化。此外，它在生物钟功能中发挥着至关重要的作用，并通过磷酸化 FMR1 有助于形成无膜区室。总体而言，CSNK2A2 作为细胞对不同刺激做出反应的中心协调者而出现，展示了其在维持细胞稳态方面的重要性。

Human

E. coli

N-SUMO;N-6*His

P68400 (R8-N350)

1457  [NCBI]

RARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSAN

56.7 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.