CXADR 蛋白, Human (HEK293, His)

CXADR proteins are components of the epithelial apical junction complex and, as cell adhesion molecules, are critical for the integrity of tight junctions. CXADR Protein, Human (HEK293, His) is the recombinant human-derived CXADR protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CXADR Protein, Human (HEK293, His) is 218 a.a., with molecular weight of ~32.0 kDa.

CXADR 蛋白作为上皮顶端连接复合物的组成部分发挥着关键作用，通过充当同质细胞粘附分子来维持紧密连接的完整性至关重要。除了其结构作用之外，CXADR 通过与 JAML（白细胞质膜上的跨膜蛋白）的粘附相互作用，积极参与促进白细胞的跨上皮迁移。这种相互作用不仅支持白细胞迁移的物理过程，而且还是激活 γ-δ T 细胞的关键介质，γ-δ T 细胞是一种存在于上皮组织中的特殊 T 细胞亚群，对组织稳态和修复至关重要。与 CXADR 结合后，JAML 在 γ-δ T 细胞中启动下游细胞信号转导事件，涉及 PI3 激酶和 MAP 激酶，导致 T 细胞增殖以及细胞因子和生长因子的产生。这一系列事件有助于刺激上皮组织修复。值得注意的是，在微生物感染的情况下，CXADR 充当 C 型腺病毒的受体。

Human

HEK293

C-6*His

P78310/NP_001329.1 (L20-G237)

1525  [NCBI]

LSITTPEEMIEKAKGETAYLPCKFTLSPEDQGPLDIEWLISPADNQKVDQVIILYSGDKIYDDYYPDLKGRVHFTSNDLKSGDASINVTNLQLSDIGTYQCKVKKAPGVANKKIHLVVLVKPSGARCYVDGSEEIGSDFKIKCEPKEGSLPLQYEWQKLSDSQKMPTSWLAEMTSSVISVKNASSEYSGTYSCTVRNRVGSDQCLLRLNVVPPSNKAG

Approximately 32.0 kDa

Greater than 92% as determined by reducing SDS-PAGE

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2. (Due to the optimization of production process, the components of different batches may vary slightly.)

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.