DR3/TNFRSF25 蛋白, Mouse (HEK293, His)

The DR3/TNFRSF25 protein displays defects in conserved residues critical for propagation feature annotation. This defect in DR3/TNFRSF25 prevents the propagation of specific functional features associated with this protein. DR3/TNFRSF25 Protein, Mouse (HEK293, His) is the recombinant mouse-derived DR3/TNFRSF25 protein, expressed by HEK293 , with C-His labeled tag. The total length of DR3/TNFRSF25 Protein, Mouse (HEK293, His) is 166 a.a., with molecular weight of 35-48 kDa.

DR3/TNFRSF25 蛋白显示出对于传播特征注释至关重要的保守残基的缺陷。DR3/TNFRSF25 的这种缺陷阻碍了与该蛋白相关的特定功能特征的传播。DR3，也称为TNFRSF25，是肿瘤坏死因子受体超家族的成员。它主要表达于免疫细胞表面，包括T细胞和自然杀伤细胞，在调节免疫反应中发挥着至关重要的作用。DR3 充当其配体 TL1A 的受体，结合后会激活各种信号通路，从而促进免疫细胞激活、增殖和细胞因子产生。DR3/TNFRSF25 中的缺陷残基对其功能及其在免疫调节中的作用的影响需要进一步研究，以揭示这种缺陷对 DR3 介导的免疫反应的影响。

1.Immobilized Mouse DR3, His Tag at 1 μg/mL (100 μl/well) on the plate. Dose response curve for Biotinylated Mouse TNFSF15, His Tag with the EC₅₀ of ≤8.8 ng/mL determined by ELISA.
2.Mouse TNFSF15, hFc Tag captured on CM5 Chip via Protein A can bind Mouse DR3, His Tag with an affinity constant of 8.98 nM as determined in SPR assay (Biacore T200).

Mouse

HEK293

C-His

B1AWN9 (Q31-M196)

85030  [NCBI]

35-48 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.