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  3. FABP5 蛋白, Human

FABP5 蛋白, Human

目录号: HY-P75214
产品使用指南

FABP5 作为长链脂肪酸和相关脂质的细胞内载体并调节配体代谢。它选择性地将特定脂肪酸从细胞质传递到细胞核,激活核受体,包括过氧化物酶体增殖物激活受体δ,促进增殖和存活。FABP5 蛋白, Human 是重组的 FABP5 蛋白,由 E. coli 表达,不带标签。FABP5 蛋白, Human 全长 135 个氨基酸,分子量约为 ~15.2 kDa。

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描述

FABP5 acts as an intracellular carrier of long-chain fatty acids and related lipids and regulates ligand metabolism. It selectively delivers specific fatty acids from the cytoplasm to the nucleus, activating nuclear receptors including peroxisome proliferator-activated receptor delta, promoting proliferation and survival. FABP5 Protein, Human is the recombinant human-derived FABP5 protein, expressed by E. coli , with tag free. The total length of FABP5 Protein, Human is 135 a.a., with molecular weight of ~15.2 kDa.

研究背景

FABP5 作为长链脂肪酸和相关活性脂质(包括内源性大麻素)的细胞内载体,从而调节它们结合的配体的代谢和作用。除了在细胞质运输中的作用外,FABP5 还选择性地将特定的脂肪酸从细胞质输送到细胞核,在那里它们激活核受体。值得注意的是,它将视黄酸递送至核受体过氧化物酶体增殖物激活受体δ,促进增殖和存活。FABP5 还可以作为中枢突触内源性大麻素的突触载体,从而控制逆行内源性大麻素信号传导。此外,它在炎症过程中通过 NF-kappa-B 激活和前列腺素 E2 (PGE2) 生物合成调节 PTGES 诱导,从而调节炎症。此外,FABP5 可能参与角质形成细胞分化。

种属

Human

表达系统

E. coli

标签

Tag Free

蛋白编号

Q01469 (M1-E135)

基因 ID
蛋白结构
N-term
FABP5 (M1-E135)
Accession # Q01469
C-term
同用名
Fatty acid-binding protein 5; E-FABP; PA-FABP; FABP5
分子量

Approximately 15.2 kDa

纯度

Greater than 90% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

FABP5 Protein, Human 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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FABP5 Protein, Human
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HY-P75214
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