FAM172A 蛋白, Human (HEK293, His)

The FAM172A protein has multiple uses in the regulation of alternative splicing, interacting with AGO2 and CHD7 to coordinate RNA processing and chromatin modification. In addition to its role in splicing, FAM172A stabilizes protein-protein interactions at the chromatin-spliceosome interface, revealing multifaceted functions. FAM172A Protein, Human (HEK293, His) is the recombinant human-derived FAM172A protein, expressed by HEK293 , with C-6*His labeled tag. The total length of FAM172A Protein, Human (HEK293, His) is 398 a.a., with molecular weight of 40-60 kDa.

FAM172A 是一种多功能蛋白质，在错综复杂的选择性剪接调控领域中发挥着至关重要的作用。它与 AGO2 和 CHD7 的相互作用表明在协调 RNA 加工和染色质修饰之间的动态相互作用中发挥着关键作用。除了在选择性剪接中的调节作用之外，FAM172A 似乎还有助于染色质-剪接体界面处蛋白质-蛋白质相互作用的稳定，强调了其在细胞过程中的多方面功能。此外，有迹象表明潜在的水解酶活性，为 FAM172A 的多种功能增添了另一层。在细胞环境中，FAM172A 与 AGO2 和 CHD7 形成复合物，这意味着在塑造 RNA 加工和染色质动力学的复杂景观方面的合作努力。

Human

HEK293

C-6*His

Q8WUF8 (Q19-L416)

83989  [NCBI]

QIQQGGPDEKEKTTALKDLLSRIDLDELMKKDEPPLDFPDTLEGFEYAFNEKGQLRHIKTGEPFVFNYREDLHRWNQKRYEALGEIITKYVYELLEKDCNLKKVSIPVDATESEPKSFIFMSEDALTNPQKLMVLIHGSGVVRAGQWARRLIINEDLDSGTQIPFIKRAVAEGYGVIVLNPNENYIEVEKPKIHVQSSSDSSDEPAEKRERKDKVSKETKKRRDFYEKYRNPQREKEMMQLYIRENGSPEEHAIYVWDHFIAQAAAENVFFVAHSYGGLAFVELMIQREADVKNKVTAVALTDSVHNVWHQEAGKTIREWMRENCCNWVSSSEPLDTSVESMLPDCPRVSAGTDRHELTSWKSFPSIFKFFTEASEAKTSSLKPAVTRRSHRIKHEEL

40-60 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.