FGG/Fibrinogen gamma chain 蛋白, Human (P.pastoris)

FGG/fibrinogen gamma chain proteins polymerize together with FGA and FGB to form the fibrin matrix, which is essential for blood clot formation. In addition to coagulation, it aids in early wound repair, stabilizes lesions, and guides cell migration. FGG/Fibrinogen gamma chain Protein, Human (P.pastoris) is the recombinant human-derived FGG/Fibrinogen gamma chain protein, expressed by P. pastoris , with tag free. The total length of FGG/Fibrinogen gamma chain Protein, Human (P.pastoris) is 285 a.a., with molecular weight of ~32.2 kDa.

纤维蛋白原 γ 链（FGG/纤维蛋白原 γ 链）蛋白与纤维蛋白原 α (FGA) 和纤维蛋白原 β (FGB) 一起聚合形成不溶性纤维蛋白基质，这是止血过程中血凝块形成的关键成分。除了在凝血中的作用外，这种蛋白质还通过稳定病变和引导细胞迁移来促进上皮细胞的早期修复。最初认为它对于血小板聚集是必需的，随后的研究表明它并不是体内血栓形成所绝对必需的。FGG/纤维蛋白原 γ 链通过 ITGB3 依赖性途径增强活化血小板中 SELP 的表达。母体纤维蛋白原对于成功妊娠至关重要，起着至关重要的作用，纤维蛋白沉积与感染相关，可防止 IFNG 介导的出血。此外，FGG/纤维蛋白原 γ 链可能通过先天和 T 细胞介导的途径促进抗菌免疫反应。该蛋白质的结构为异六聚体，具有两组三个不相同的链（α、β 和 γ），其构象将 N 末端置于一个小的中央结构域中。

Human

P. pastoris

Tag Free

P02679 (V169-L453)

2266  [NCBI]

Approximately 32.2 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.