FSH 蛋白, Human (HEK293, Fc)

The CG alpha protein, a shared alpha chain in glycoprotein hormones (TSH, LH, FSH, CG), binds to receptors, initiating signaling pathways. Heterodimeric hormones involve CG alpha and a specific beta chain (TSHB, LHB, FSHB, CGB), imparting biological specificity. FSH Protein, Human (HEK293, Fc) is a recombinant protein dimer complex containing human-derived FSH protein, expressed by HEK293 , with C-hFc labeled tag. FSH Protein, Human (HEK293, Fc), has molecular weight of ~23-24.3 & 45-49 kDa, respectively.

CG α 蛋白作为活性异二聚体糖蛋白激素中的共享 α 链，包括促甲状腺素 (TSH)、促黄体激素 (LH)、促卵泡素 (FSH) 和绒毛膜促性腺激素 (CG)。这些激素与靶细胞上的特定受体结合，启动下游信号通路。这些激素的异二聚体结构涉及 CG α 链（如此处所述）和独特的 β 链，该链赋予每种激素生物特异性。具体地，TSH由CGα和TSHβ(TSHB)组成，促卵泡素由CGα和LHβ(LHB)组成，促卵泡素包括CGα和FSHβ(FSHB)，绒毛膜促性腺激素由CGα和绒毛膜促性腺激素亚基β(CGB)组成。。

Measured in a cell proliferation assay using SK-OV-3 cells. The ED₅₀ for this effect is ≤0.076 ng/mL, corresponding to a specific activity is ≥1.316×10⁷ units/mg.

• 
  Measured in a cell proliferation assay using SK-OV-3 cells. The ED₅₀ for this effect is 0.055 ng/mL, corresponding to a specific activity is 1.82×10₇ units/mg.

Human

HEK293

C-hFc

P01215 (A25-S116) & P01225 (N19-E129)

1081  [NCBI]&2488  [NCBI]

APDVQDCPECTLQENPFFSQPGAPILQCMGCCFSRAYPTPLRSKKTMLVQKNVTSESTCCVAKSYNRVTVMGGFKVENHTACHCSTCYYHKS
&:
NSCELTNITIAIEKEECRFCISINTTWCAGYCYTRDLVYKDPARPKIQKTCTFKELVYETVRVPGCAHHADSLYTYPVATQCHCGKCDSDSTDCTVRGLGPSYCSFGEMKE

Approximately 23-24.3 & 45-49 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 50 mM Tris, 100 mM NaCl, pH 8.0 or PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.