2. 重组蛋白
  3. Cytokines and Growth Factors
  4. TGF-beta Superfamily Neurotrophic Factors
  5. GDNF family
  6. GFR alpha-2
  7. GFRA2/GDNFR-alpha-2 蛋白, Human (HEK293, His)

GFRA2/GDNFR-alpha-2 蛋白, Human (HEK293, His)

目录号: HY-P70192
产品使用指南

GFRA2，也称为 GDNFR-α-2，作为神经营养因子 (NRTN) 的受体，促进 NRTN 诱导的自身磷酸化和 RET 受体激活。除了神经营养因子信号传导之外，GFRA2 还可以通过 RET 酪氨酸激酶介导 GDNF 信号传导。GFRA2/GDNFR-alpha-2 蛋白, Human (HEK293, His) 是重组的 GFRA2/GDNFR-alpha-2 蛋白，由 HEK293 表达，带有 C-6*His 标签。GFRA2/GDNFR-alpha-2 蛋白, Human (HEK293, His) 全长 420 个氨基酸，分子量约为 ~80.0 kDa。

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描述

GFRA2, also known as GDNFR-α-2, acts as a receptor for neurotrophic factor (NRTN) and promotes NRTN-induced autophosphorylation and RET receptor activation. In addition to neurotrophic factor signaling, GFRA2 can also mediate GDNF signaling through the RET tyrosine kinase. GFRA2/GDNFR-alpha-2 Protein, Human (HEK293, His) is the recombinant human-derived GFRA2/GDNFR-alpha-2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of GFRA2/GDNFR-alpha-2 Protein, Human (HEK293, His) is 420 a.a., with molecular weight of ~80.0 kDa.
研究背景

GFRA2，也称为 GDNFR-α-2，作为神经营养因子 (NRTN) 的受体，促进 NRTN 诱导的自磷酸化和 RET 受体的激活。除了在神经营养因子信号传导中发挥作用外，GFRA2 还具有通过 RET 酪氨酸激酶受体介导 GDNF 信号传导的能力。值得注意的是，GFRA2 在 NRTN 诱导的 STAT3“Ser-727”磷酸化中发挥作用，突出显示其参与下游信号通路的激活。因此，这种多面受体有助于神经营养因子和 GDNF 通过 RET 受体协调的复杂细胞反应。
种属

Human
表达系统

HEK293
标签

C-6*His
蛋白编号

O00451 (S22-S441)
基因 ID
蛋白结构
N-term
GFRA2 (S22-S441)
Accession # O00451
6*His
C-term
同用名
rHuGDNF family receptor alpha-2/GFRA2, His ; GDNF Family Receptor Alpha-2; GDNF Receptor Alpha-2; GDNFR-Alpha-2; GFR-Alpha-2; GDNF Receptor Beta; GDNFR-Beta; Neurturin Receptor Alpha; NRTNR-Alpha; NTNR-Alpha; RET Ligand 2; TGF-Beta-Related Neurotrophic Factor Receptor 2; GFRA2; GDNFRB; RETL2; TRNR2
氨基酸序列

SPSSLQGPELHGWRPPVDCVRANELCAAESNCSSRYRTLRQCLAGRDRNTMLANKECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGEEFYEASPYEPVTSRLSDIFRLASIFSGTGADPVVSAKSNHCLDAAKACNLNDNCKKLRSSYISICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPSCSYEDKEKPNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVTSCPADNYQACLGSYAGMIGFDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLRDFTENPCLRNAIQAFGNGTDVNVSPKGPSFQATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTSVQEQGLKANNSKELSMCFTELTTNIIPGSNKVIKPNS

分子量

Approximately 80.0 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

GFRA2/GDNFR-alpha-2 Protein, Human (HEK293, His) 相关分类

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