2. 重组蛋白
  3. Enzymes & Regulators
  4. Transferases (EC 2)
  5. GGPS1 蛋白, Human (His)

GGPS1 蛋白, Human (His)

目录号: HY-P70224
产品使用指南

GGPS1蛋白负责催化三分子异戊烯基焦磷酸（IPP）与二甲基烯丙基焦磷酸（DMAPP）反式加成，合成香叶基香叶基焦磷酸。该化合物是类胡萝卜素和香叶化蛋白质生物合成的重要前体。GGPS1 蛋白, Human (His) 是重组的 GGPS1 蛋白，由 E. coli 表达，带有 N-6*His 标签。GGPS1 蛋白, Human (His) 全长 300 个氨基酸，分子量约为 ~35.0 kDa。

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100 μg   询价  

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描述

The GGPS1 protein is responsible for catalyzing the trans-addition of three molecules of isopentenyl pyrophosphate (IPP) to dimethylallyl pyrophosphate (DMAPP) to synthesize geranylgeranyl pyrophosphate. This compound is an important precursor for the biosynthesis of carotenoids and geranylated proteins. GGPS1 Protein, Human (His) is the recombinant human-derived GGPS1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of GGPS1 Protein, Human (His) is 300 a.a., with molecular weight of ~35.0 kDa.
研究背景

香叶基香叶基焦磷酸合成酶 (GGPS1) 是一种催化三分子异戊烯基焦磷酸 (IPP) 反式加成到二甲基烯丙基焦磷酸 (DMAPP) 上的酶，从而形成香叶基香叶基焦磷酸 (GGPP)。GGPP 是各种重要分子（包括类胡萝卜素和香叶化蛋白）生物合成的重要前体。类胡萝卜素是具有抗氧化特性的重要色素，而香叶化蛋白则参与细胞信号传导和调节。GGPS1 的酶活性对于 GGPP 的合成至关重要，为生产具有生物学意义的化合物提供了关键的构建模块。了解 GGPS1 的功能可以深入了解与色素沉着、抗氧化防御和细胞信号传导相关的途径的调节。参考资料：所提供的信息基于截至 2022 年 1 月的一般知识，未引用具体参考资料。
种属

Human
表达系统

E. coli
标签

N-6*His
蛋白编号

O95749 (M1-E300)
基因 ID
蛋白结构
N-term
6*His
GGPS1 (M1-E300)
Accession # O95749
C-term
同用名
rHuGeranylgeranyl pyrophosphate synthase/GGPS1, His; Geranylgeranyl Pyrophosphate Synthase; GGPP Synthase; GGPPSase; (2E; 6E)-Farnesyl Diphosphate Synthase; Dimethylallyltranstransferase; Farnesyl Diphosphate Synthase; Farnesyltranstransferase; Geranylgeranyl Diphosphate Synthase; Geranyltranstransferase; GGPS1
氨基酸序列

MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE

分子量

Approximately 35.0 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

GGPS1 Protein, Human (His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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