GLP1R 蛋白, Mouse (His-SUMO)

GLP1R protein, a G-protein coupled receptor, binds to GLP-1, activating adenylyl cyclase and increasing intracellular cAMP levels. This interaction regulates insulin secretion and maintains glucose homeostasis. GLP1R can also form dimers with GIPR, suggesting complex regulatory mechanisms and interactions with other receptors. GLP1R Protein, Mouse (His-SUMO) is the recombinant mouse-derived GLP1R protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of GLP1R Protein, Mouse (His-SUMO) is 124 a.a., with molecular weight of ~30.4 kDa.

GLP1R 是一种 G 蛋白偶联受体，与胰高血糖素样肽 1 (GLP-1) 特异性结合，启动信号级联反应，激活腺苷酸环化酶，导致细胞内 cAMP 水平升高。这种分子相互作用在响应 GLP-1 的胰岛素分泌调节中发挥着关键作用，有助于葡萄糖稳态。此外，GLP1R 表现出与 GIPR 受体形成同二聚体和异二聚体的潜力，表明其调节机制以及与细胞环境中其他受体的相互作用可能存在复杂性。

Mouse

E. coli

N-6*His;N-SUMO

O35659 (G22-Y145)

14652  [NCBI]

GPRPQGTTVSLSETVQKWREYRRQCQRFLTEAPLLATGLFCNRTFDDYACWPDGPPGSFVNVSCPWYLPWASSVLQGHVYRFCTAEGLWLHKDNSSLPWRDLSECEESKRGERNFPEEQLLSLY

Approximately 30.4 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm solution of Tris-based buffer, 50% Glycerol.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.