Glucose-6-phosphate isomerase 蛋白, Human (His)

Glucose-6-phosphate isomerase protein is a key player in glycolysis, catalyzing the conversion of glucose-6-phosphate into fructose-6-phosphate in the cytoplasm. It carries out this reaction reversibly during gluconeogenesis. Glucose-6-phosphate isomerase Protein, Human (His) is the recombinant human-derived Glucose-6-phosphate isomerase protein, expressed by E. coli , with N-6*His labeled tag. The total length of Glucose-6-phosphate isomerase Protein, Human (His) is 553 a.a., with molecular weight of ~65.0 kDa.

在细胞质中，6-磷酸葡萄糖异构酶蛋白通过催化 6-磷酸葡萄糖转化为 6-磷酸果糖，在糖酵解中发挥关键作用，代表该代谢途径的第二步，并且它可逆地执行该反应在糖异生过程中。除了作为糖酵解酶的功能外，这种蛋白质还表现出作为分泌细胞因子的额外作用。作为血管生成因子 (AMF)，它可以刺激内皮细胞运动，促进血管生成。此外，6-磷酸葡萄糖异构酶充当神经营养因子，称为神经白介素，特别有益于脊髓和感觉神经元。值得注意的是，它由凝集素刺激的 T 细胞分泌，诱导免疫球蛋白分泌，突出了其在各种生理过程中细胞内和细胞外的多样化和多功能作用。

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Human

E. coli

N-6*His

P06744 (A2-E554)

2821  [NCBI]

AALTRDPQFQKLQQWYREHRSELNLRRLFDANKDRFNHFSLTLNTNHGHILVDYSKNLVTEDVMRMLVDLAKSRGVEAARERMFNGEKINYTEGRAVLHVALRNRSNTPILVDGKDVMPEVNKVLDKMKSFCQRVRSGDWKGYTGKTITDVINIGIGGSDLGPLMVTEALKPYSSGGPRVWYVSNIDGTHIAKTLAQLNPESSLFIIASKTFTTQETITNAETAKEWFLQAAKDPSAVAKHFVALSTNTTKVKEFGIDPQNMFEFWDWVGGRYSLWSAIGLSIALHVGFDNFEQLLSGAHWMDQHFRTTPLEKNAPVLLALLGIWYINCFGCETHAMLPYDQYLHRFAAYFQQGDMESNGKYITKSGTRVDHQTGPIVWGEPGTNGQHAFYQLIHQGTKMIPCDFLIPVQTQHPIRKGLHHKILLANFLAQTEALMRGKSTEEARKELQAAGKSPEDLERLLPHKVFEGNRPTNSIVFTKLTPFMLGALVAMYEHKIFVQGIIWDINSFDQWGVELGKQLAKKIEPELDGSAQVTSHDASTNGLINFIKQQRE

Approximately 65.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm sterile filtered PBS, 6% Trehalose, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.