GPR62 蛋白, Human (Cell-Free, His)

The GPR62 protein is an orphan G protein-coupled receptor that continuously activates the G(q/11)/phosphoinositide and G(s)-α/cAMP pathways. It exhibits spontaneous β-arrestin recruitment and may reciprocally regulate signaling through heteromerization, especially with MTNR1B. GPR62 Protein, Human (Cell-Free, His) is the recombinant human-derived GPR62 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of GPR62 Protein, Human (Cell-Free, His) is 368 a.a., with molecular weight of 39.1 kDa.

GPR62 蛋白是一种孤儿 G 蛋白偶联受体，表现出 G(q/11)/磷酸肌醇和 G(s)-α/cAMP 信号通路的组成型激活。值得注意的是，它表现出 β-抑制蛋白募集的自发活性，并参与信号传导功能的相互调节，这可能归因于受体异聚化，特别是与褪黑激素受体 MTNR1B 的异聚化。GPR62 形成同二聚体并与 MTNR1B 形成异二聚体。该蛋白还以自发且不依赖激动剂的方式与 ARRB1 和 ARRB2 相互作用，导致 GPR62 内化到内体区室中。这些动态相互作用强调了 GPR62 在细胞信号通路中的多方面调节作用。

Human

E. coli Cell-free

N-10*His

Q9BZJ7 (M1-S368)

118442

MANSTGLNASEVAGSLGLILAAVVEVGALLGNGALLVVVLRTPGLRDALYLAHLCVVDLLAAASIMPLGLLAAPPPGLGRVRLGPAPCRAARFLSAALLPACTLGVAALGLARYRLIVHPLRPGSRPPPVLVLTAVWAAAGLLGALSLLGTPPAPPPAPARCSVLAGGLGPFRPLWALLAFALPALLLLGAYGGIFVVARRAALRPPRPARGSRLHSDSLDSRLSILPPLRPRLPGGKAALAPALAVGQFAACWLPYGCACLAPAARAAEAEAAVTWVAYSAFAAHPFLYGLLQRPVRLALGRLSRRALPGPVRACTPQAWHPRALLQCLQRPPEGPAVGPSEAPEQTPELAGGRSPAYQGPPESSLS

39.1 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.