Growth Hormone R/GHR 蛋白, Rhesus macaque (HEK293, Fc)

GHR Protein, a cell surface receptor, is involved in growth regulation and metabolism. Dysregulation of GHR Protein has been linked to conditions such as growth hormone deficiency and metabolic disorders. Targeting GHR Protein may offer potential therapeutic interventions in these conditions by regulating growth, improving metabolism, and managing related disorders. Growth Hormone R/GHR Protein, Rhesus macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived Growth Hormone R/GHR protein, expressed by HEK293 , with C-hFc labeled tag.

GHR 蛋白是垂体生长激素的受体，在调节产后身体生长方面发挥着至关重要的作用。与其配体结合后，GHR 激活 JAK2/STAT5 通路，从而启动下游信号传导事件。此外，可溶形式的 GHR（称为 GHBP）可作为血浆中生长激素的储存库，并可作为 GH 信号传导的调节剂或抑制剂。

Measured in a cell proliferation assay using NB2-11 cells. The ED₅₀ for this effect is 0.8665 ng/mL in the presence of 0.2 ng/mL of rhGH, corresponding to a specific activity is 1.15×10^6 units/mg.

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  Measured in a cell proliferation assay using NB2-11 cells. The ED₅₀ this effect is 0.8665 ng/mL in the presence of 0.2 ng/mL of rhGH, corresponding to a specific activity is 1.15×10⁶units/mg

Rhesus Macaque

HEK293

C-hFc

P79194 (F19-Y264)

697986  [NCBI]

FSGSEPTAAILSRASWSLQSVNPGLKTNSSKEPKFTKCRSPERETFSCHWTDAVHHGSKSLGPIQLFYTRRNIQGQTQEWKECPDYVSAGENSCYFNSSFTSVWIPYCIKLTSNGDTVDGKCFSVDEIVQPDPPIALNWTLLNVSLTGIHADILVRWEAPPNADIQKGWMVLEYELQYKEVNETKWKMMDPILSTSVPVYSLKVDKEYEVLVRSKRRNSRNYGEFSEVLYVTLPQMNQFTCEEDFY

65-93 kDa band in SDS-PAGE under reducing conditions due to the glycosylation.

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized a 0.22 μm filtered solution of 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH 7.5.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.