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  3. H2BC11 蛋白, Human

H2BC11 蛋白, Human

目录号: HY-P72329
产品使用指南

H2BC11 蛋白作为核小体的核心成分发挥作用,核小体是染色质结构中包裹和压缩 DNA 的基本单位,调节其对需要 DNA 作为模板的细胞过程的可及性。组蛋白(包括 H2BC11)在转录调节、DNA 修复、DNA 复制和染色体稳定性中发挥着核心作用。H2BC11 蛋白, Human 是重组的 H2BC11 蛋白,由 E. coli 表达,不带标签。H2BC11 蛋白, Human 全长 125 个氨基酸,分子量约为 ~13.8 kDa。

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描述

The H2BC11 protein functions as a core component of nucleosomes, the fundamental units in chromatin structure that wrap and compact DNA, regulating its accessibility to cellular processes that require DNA as a template. Histones, including H2BC11, play central roles in transcriptional regulation, DNA repair, DNA replication, and chromosome stability. H2BC11 Protein, Human is the recombinant human-derived H2BC11 protein, expressed by E. coli , with tag free. The total length of H2BC11 Protein, Human is 125 a.a., with molecular weight of ~13.8 kDa.

研究背景

组蛋白 H2BC11 是核小体的重要组成部分,核小体是染色质的基本单位,负责包裹和压缩 DNA。这种压缩限制了 DNA 对细胞机器的可及性,影响转录调控、DNA 修复、复制和染色体稳定性。组蛋白(包括 H2BC11)在这些过程中发挥着核心作用。DNA 可及性的调节涉及一系列复杂的翻译后修饰(称为组蛋白密码)和核小体重塑。除了在染色质组织中的作用之外,H2BC11 还表现出广泛的抗菌活性,表明它可能参与结肠上皮功能性抗菌屏障的形成。此外,H2BC11 可能有助于羊水的杀菌活性,将其功能意义扩展到染色质动力学之外,以宿主针对微生物威胁的防御机制。

种属

Human

表达系统

E. coli

标签

Tag Free

蛋白编号

P06899 (P2-K126)

基因 ID
蛋白结构
N-term
H2BC11 (P2-K126)
Accession # P06899
C-term
同用名
H2BC11; Histone H2B type 1-J
氨基酸序列

PEPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSAK

分子量

Approximately 13.8 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

H2BC11 Protein, Human 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
H2BC11 Protein, Human
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HY-P72329
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