HNF 4 alpha (HNF4A) Recombinant 蛋白,Human(C-His)

HNF 4 alpha, a nuclear transcription factor, forms homodimers to bind DNA. It regulates gene expression, including hepatocyte nuclear factor 1 alpha, impacting hepatic genes. Its involvement extends to liver, kidney, and intestinal development. Mutations associate with autosomal dominant non-insulin-dependent diabetes mellitus type I. The gene exhibits biased expression in the duodenum (RPKM 37.7) and colon (RPKM 32.8), among other tissues. HNF 4 alpha (HNF4A) Recombinant Protein,Human (C-His) is the recombinant human-derived HNF 4 alpha, expressed by HEK293 , with C-10*His labeled tag. The total length of HNF 4 alpha (HNF4A) Recombinant Protein,Human (C-His) is 474 a.a., with molecular weight of ~70-80 kDa.

HNF 4 α 是该基因的蛋白质产物，充当核转录因子，形成同二聚体以结合 DNA 并控制各种基因的表达，包括肝细胞核因子 1 α（肝基因表达的关键调节因子）。它的参与延伸到肝脏、肾脏和肠道等重要器官的发育。HNF 4α 突变与单基因常染色体显性非胰岛素依赖型 I 型糖尿病有关，强调了其在代谢调节中的重要性。此外，选择性剪接会产生多种转录变体，从而产生不同的亚型。值得注意的是，HNF 4 α 表现出偏向表达，在十二指肠 (RPKM 37.7)、结肠 (RPKM 32.8) 和其他七个组织中观察到较高水平，强调了其在不同生理环境中的特殊作用。

Human

HEK293

C-10*His

NP_000448 (M1-I474)

3172

MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEWPRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI

Approximately 70-80 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液

Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 10% glycerol, pH 7.3.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.