IAPP 蛋白, Human (GST)

The IAPP protein selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, affecting glucose metabolism without affecting adipocytes. IAPP interacts with IDE (insulin-degrading enzyme) and insulin (INS) to form homodimers, affecting their fibril formation. IAPP Protein, Human (GST) is the recombinant human-derived IAPP protein, expressed by E. coli , with N-GST labeled tag. The total length of IAPP Protein, Human (GST) is 37 a.a., with molecular weight of ~31.4 kDa.

IAPP 蛋白可选择性抑制肌肉中胰岛素刺激的葡萄糖利用和糖原沉积，对肌肉葡萄糖代谢产生特定影响，而不影响脂肪细胞。已知该蛋白质可与 IDE（胰岛素降解酶）和胰岛素 (INS) 相互作用，形成同二聚体作为其功能机制的一部分。值得注意的是，与胰岛素的相互作用不仅影响 IAPP 的同二聚化，而且还抑制原纤维形成，表明在调节与 IAPP 相关的原纤维结构组装中具有调节作用。这些相互作用凸显了 IAPP 在葡萄糖代谢调节中复杂的相互作用及其与关键分子伙伴的动态关系。

Human

E. coli

N-GST

P10997 (K34-Y70)

3375  [NCBI]

KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY

Approximately 31.4 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm solution of PBS, 6% Trehalose, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.