1. 重组蛋白
  2. Cytokines and Growth Factors
  3. Interferon & Receptors
  4. IFN-beta
  5. IFN-beta 蛋白, Rhesus (HEK293, Fc)

IFN-beta 蛋白, Rhesus (HEK293, Fc)

目录号: HY-P73132
产品使用指南

IFN-beta 蛋白是 1 型干扰素家族具有免疫调节作用的细胞因子。IFN-beta 蛋白 通过抑制 RANKL-c-Fos 信号通路减少关节炎症。IFN-beta 蛋白 通过 STAT5、PGAM5 和 Drp1 调节线粒体裂变来拯救神经退行性病变。IFN-beta 蛋白, Rhesus (HEK293, Fc) 是重组的 IFN-β 蛋白,由 HEK293 表达,带有 C-mFc 标签。IFN-beta 蛋白, Rhesus (HEK293, Fc) 全长 166 个氨基酸,分子量约为 ~46.4 kDa。

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     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

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描述

IFN-beta Protein is an immunomodulatory cytokine of the type 1 interferon family. IFN-beta Protein reduces joint inflammation by inhibiting the RANKL-c-Fos signaling pathway. IFN-beta Protein regulates mitochondrial fission through STAT5, PGAM5, and Drp1 to rescue neurodegeneration. IFN-beta Protein, Rhesus (HEK293, Fc) is the recombinant Rhesus Macaque-derived IFN-beta protein, expressed by HEK293 , with C-mFc labeled tag. The total length of IFN-beta Protein, Rhesus (HEK293, Fc) is 166 a.a., with molecular weight of ~46.4 kDa.

研究背景

干扰素 (IFN) 构成一个家族自然分泌具有免疫调节作用的细胞因子功能。它们增强了巨噬细胞摧毁肿瘤细胞、病毒和细菌。IFN 有两种类型:1 型 IFN 包括 IFN-α和 β,2 型 IFN 仅由 IFN- γ 组成。IFN-beta 和 IFN-gamma 有相反的作用,IFN-gamma 促进炎症反应,而 IFN-beta 主要是抗炎特性。外源性 IFN-beta 通过抑制 RANKL-c-Fos 信号通路减少关节炎症。IFN-beta 通过激活 STAT5、PGAM5 和 Drp1 调节线粒体裂变来拯救神经退行性病变。

种属

Rhesus Macaque

表达系统

HEK293

标签

C-mFc

蛋白编号

EHH24077.1 (M22-N187)

基因 ID

/

蛋白结构
N-term
IFN-beta (M22-N187)
Accession # EHH24077.1
mFc
C-term
同用名
Interferon beta; IFN-beta; IFNB1; IFB; IFNB
分子量

Approximately 46.4 kDa

纯度

Greater than 85% as determined by reducing SDS-PAGE

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

IFN-beta Protein, Rhesus (HEK293, Fc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
IFN-beta Protein, Rhesus (HEK293, Fc)
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HY-P73132
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