IFN-lambda 2/IL-28A 蛋白, Mouse (HEK293, His, solution)

IFN-lambda 2/IL-28A Protein, Mouse (HEK 293, His), a type III interferon, is a member of IL-10-interferon family. IFN-lambda 2/IL-28A Protein shows anti-viral, anti-tumor and immune stimulatory properties.

干扰素 lambda（IFN-λ；IFNL1-4）通过诱导基因网络调节感染和自身免疫性疾病背景下的免疫力。IL-28A、IL-28B 和 IL-29（也称为 III 型干扰素）构成了 IL-10 干扰素家族中的一个新亚家族。IL-28A、IL-28B 和 IL-29 共享一个共同的细胞受体，由细胞因子受体家族 II 类成员 IL-28R1（也称为 IFN-λR1、LICR2 和 CRF2/12）和 IL-10R2 组成。IL-28A 显示可减少病毒复制或一系列病毒的细胞病变效应，包括 DNA 病毒鼠 CMV、乙型肝炎病毒和单纯疱疹病毒 2、ss (+) RNA 病毒 EMCV、西尼罗河病毒和丙型肝炎病毒，以及 ss (-) RNA 病毒、水泡性口炎病毒、甲型流感病毒和汉坦病毒^[1][2]。

Mouse

HEK293

N-6*His

Q4VK74 (D20-193V)

330496  [NCBI]

DPVPRATRLPVEAKDCHIAQFKSLSPKELQAFKKAKDAIEKRLLEKDLRCSSHLFPRAWDLKQLQVQERPKALQAEVALTLKVWENMTDSALATILGQPLHTLSHIHSQLQTCTQLQATAEPRSPSRRLSRWLHRLQEAQSKETPGCLEASVTSNLFRLLTRDLKCVANGDQCV

Approximately 21.8 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.

• [1]. Syedbasha M, et, al. Interferon Lambda: Modulating Immunity in Infectious Diseases. Front Immunol. 2017 Feb 28;8:119.  [Content Brief]

  [2]. Witte K, et, al. IL-28A, IL-28B, and IL-29: promising cytokines with type I interferon-like properties. Cytokine Growth Factor Rev. 2010 Aug;21(4):237-51.  [Content Brief]