IL-17A 蛋白, Rat (CHO)

The IL-17A protein has important heterodimerization and homodimerization activities and is involved in a variety of processes, including responses to glucocorticoid stimulation and the regulation of cell death and transcription. IL-17A is present in the cytoplasm and extracellular space and has been implicated in diseases such as pancreatitis, inflammatory bowel disease, renal disease, and periodontal disease, and may serve as a biomarker. IL-17A Protein, Rat (CHO) is the recombinant rat-derived IL-17A protein, expressed by CHO , with tag free. The total length of IL-17A Protein, Rat (CHO) is 133 a.a., with molecular weight of 13-22 kDa.

IL-17A 蛋白预计在蛋白质异二聚化和同二聚化活性中发挥关键作用。它参与多种生物过程，包括细胞对糖皮质激素刺激的反应、坏死细胞死亡的正向调节以及 RNA 聚合酶 II 转录的正向调节。这种蛋白质存在于细胞质和细胞外空间中。IL-17A 与多种疾病有关，包括急性坏死性胰腺炎、炎症性肠病、类脂性肾病、肺病和牙周病，可作为这些疾病的生物标志物。它还与特定疾病有关，例如抗基底膜肾小球肾炎、充血性心力衰竭、心肌炎、胸膜炎和葡萄膜炎。此外，IL-17A 的人类直系同源物白细胞介素 17A 与鸟分枝杆菌复合体疾病、自身免疫性疾病、支气管疾病、黄斑变性和鼻炎等疾病有关。尽管 IL-17A 在参考数据集中的表达量较低，但它仍然是免疫反应和疾病病理学中的关键角色。

Measured by its ability to induce IL-6 secretion by NIH-3T3 mouse embryonic fibroblast cells. The ED₅₀ for this effect is <7 ng/mL, corresponding to a specific activity is >1.43×10⁵ U/mg.

• 
  Measured by its ability to induce IL-6 secretion by NIH‑3T3 mouse embryonic fibroblast cells. The ED50 for this effect is <7 ng/mL, corresponding to a specific activity is >1.43×10⁵ U/mg.

Rat

CHO

Tag Free

NP_001100367 (A26-S158)

301289  [NCBI]

AVLIPQSSVCPNAEANNFLQNVKVNLKVLNSLSSKASSRRPSDYLNRSTSPWTLSRNEDPDRYPSVIWEAQCRHQRCVNAEGKLDHHMNSVLIQQEILVLKREPEKCPFTFRVEKMLVGVGCTCVSSIVRHAS

13-22 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.