IL1R1 蛋白, Human (Cell-Free, His, SUMO, Myc)

IL1R1 protein is the receptor for IL1A, IL1B and IL1RN and forms a high-affinity complex with IL1RAP upon ligand binding. This complex activates NF-kappa-B, MAPK and other pathways, recruiting adapter molecules such as TOLLIP, MYD88 and IRAK1 or IRAK2. IL1R1 Protein, Human (Cell-Free, His, SUMO, Myc) is the recombinant human-derived IL1R1 protein, expressed by E. coli Cell-free , with N-10*His, C-Myc, N-SUMO labeled tag. The total length of IL1R1 Protein, Human (Cell-Free, His, SUMO, Myc) is 552 a.a., with molecular weight of 83.5 kDa.

IL1R1 是白细胞介素 1A (IL1A)、白细胞介素 1B (IL1B) 和白细胞介素 1 受体拮抗剂 (IL1RN) 的受体，在配体结合后与辅助受体 IL1RAP 形成高亲和力复合物。该复合物介导 NF-kappa-B 和 MAPK 等信号通路的 IL-1 依赖性激活。信号级联涉及通过受体/辅助受体亚基的 TIR 结构域招募接头分子，包括 TOLLIP、MYD88 和 IRAK1 或 IRAK2。IL1R1 以相当的亲和力结合配体，并且与拮抗剂 IL1RN 的相互作用阻止与 IL1RAP 的结合，从而抑制信号复合物的形成。此外，IL1R1 参与 IL1B 介导的辅助 T 细胞 1 (Th1) 细胞产生 IFNG 的共刺激。

Human

E. coli Cell-free

N-10*His;C-Myc;N-SUMO

P14778 (L18-G569)

3554

LEADKCKEREEKIILVSSANEIDVRPCPLNPNEHKGTITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAKFVENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKPLLLDNIHFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKPTRPVIVSPANETMEVDLGSQIQLICNVTGQLSDIAYWKWNGSVIDEDDPVLGEDYYSVENPANKRRSTLITVLNISEIESRFYKHPFTCFAKNTHGIDAAYIQLIYPVTNFQKHMIGICVTLTVIIVCSVFIYKIFKIDIVLWYRDSCYDFLPIKASDGKTYDAYILYPKTVGEGSTSDCDIFVFKVLPEVLEKQCGYKLFIYGRDDYVGEDIVEVINENVKKSRRLIIILVRETSGFSWLGGSSEEQIAMYNALVQDGIKVVLLELEKIQDYEKMPESIKFIKQKHGAIRWSGDFTQGPQSAKTRFWKNVRYHMPVQRRSPSSKHQLLSPATKEKLQREAHVPLG

83.5 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.