Integrin alpha 2 beta 1 蛋白, Mouse (HEK293, His)

Integrin alpha-2/beta-1, a pivotal collagen receptor, centralizes platelet and cell adhesion to collagens, modulating collagen and collagenase gene expression. Beyond collagen-related functions, it contributes to force generation, extracellular matrix organization, and recognizes laminins, collagen C-propeptides, and E-cadherin. Mice with a null mutation in the alpha-2 subunit face early mortality, emphasizing its critical role in developmental processes. Structurally, forming a heterodimeric complex with beta-1, Integrin alpha-2/beta-1 interacts with HPS5 and RAB21, revealing multifaceted regulatory and signaling functions. Integrin alpha 2 beta 1 Protein, Mouse (HEK293, His) is a recombinant protein dimer complex containing mouse-derived Integrin alpha 2 beta 1 protein, expressed by HEK293, with C-His labeled tag. Integrin alpha 2 beta 1 Protein, Mouse (HEK293, His), has molecular weight of 128-138 kDa (ITGA2) & 105-115 kDa (ITGB1), respectively.

整合素 α-2/β-1 蛋白作为关键的胶原蛋白受体，在血小板和细胞与胶原蛋白的粘附以及胶原蛋白和胶原酶基因表达的调节中发挥核心作用。除了与胶原蛋白相关的功能外，它还有助于力的产生和新合成的细胞外基质的组织。此外，整合素 α-2/β-1 充当多功能受体，识别层粘连蛋白、胶原 C 前肽和 E-钙粘蛋白。在胚胎发生过程中，α-2 亚基无突变的小鼠面临早期死亡，这强调了整合素 α-2/β-1 在发育过程中的关键作用。在结构上，它形成异二聚体复合物，其中 α-2 亚基与 β-1 结合。该蛋白进一步与 HPS5 和 RAB21 相互作用，揭示了其调控和信号传导功能的额外维度。总体而言，整合素 α-2/β-1 在介导细胞与细胞外基质的相互作用和影响重要的发育过程中发挥着关键作用。

Mouse

HEK293

C-His

Q62469 (Y27-T1129)&P09055-1 (Q21-D728)

16398

128-138 kDa(ITGA2) & 105-115 kDa(ITGB1)

Greater than 95% as determined by reducing Tris-Bis PAGE.

无菌粉末.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.