Integrin alpha V beta 6 蛋白, Mouse (HEK293, Flag-His)

Integrin alpha V beta 6 protein, a key member of the integrin superfamily, crucially engages in cell adhesion and signaling through heterodimer formation with beta chains, including beta 1, beta 3, beta 6, and beta 8. As the Vitronectin receptor, the alpha V beta 3 heterodimer interacts with multiple extracellular matrix proteins, mediating cell adhesion and influencing cell migration. Its deficiency in mice leads to vascular morphogenesis defects in the brain and early post-natal mortality. Integrin alpha V beta 6 is widely expressed, notably in tissues like adult placenta and ovary. Integrin alpha V beta 6 Protein, Mouse (HEK293, Flag-His) is a recombinant protein dimer complex containing mouse-derived Integrin alpha V beta 6 protein, expressed by HEK293, with C-His, C-Flag labeled tag. Integrin alpha V beta 6 Protein, Mouse (HEK293, Flag-His), has molecular weight of ~190.4 kDa.

整合素 α V β 6 蛋白是整合素超家族的成员，通过与各种 β 链（包括 β 1、β 3、β 6 和 β 8）形成异二聚体，在细胞粘附和信号转导中发挥着至关重要的作用。α V β 3异二聚体起到玻连蛋白受体的作用。该蛋白与多种细胞外基质蛋白相互作用，介导细胞粘附并参与细胞迁移。在小鼠中，该基因的缺陷与大脑血管形态发生缺陷和产后早期死亡率有关。整合素αVβ6蛋白的表达广泛，在成人胎盘和卵巢等多种组织中观察到。

Mouse

HEK293

C-His;C-Flag

NP_032428.2 (F31-V988)&NP_067334 (G22-P708)

16410  [NCBI]&16420

Approximately 190.4 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.