LACTB2 蛋白, Human (GST)

As an endoribonuclease, LACTB2 protein preferentially cleaves the 3' purine-pyrimidine dinucleotide motif within single-stranded RNA, producing a cleavage product with a free 3'-OH group. It is worth noting that its enzymatic activity is only directed against single-stranded RNA and does not extend to double-stranded RNA or DNA. LACTB2 Protein, Human (GST) is the recombinant human-derived LACTB2 protein, expressed by E. coli , with N-GST labeled tag. The total length of LACTB2 Protein, Human (GST) is 288 a.a., with molecular weight of ~56.0 kDa.

LACTB2 蛋白作为核糖核酸内切酶发挥作用，表现出优先在嘌呤-嘧啶二核苷酸基序的 3' 处切割单链 RNA。所得裂解产物保留游离的 3'-OH 基团。值得注意的是，LACTB2 缺乏双链 RNA 或 DNA 的活性。它的作用对于维持正常的线粒体功能和确保细胞活力至关重要。特定的底物偏好及其对 RNA 裂解的参与突出了 LACTB2 在调节线粒体内 RNA 加工中的重要性，强调了其在细胞和线粒体稳态中的关键作用。（

Human

E. coli

N-GST

Q53H82 (M1-L288)

51110  [NCBI]

MAAVLQRVERLSNRVVRVLGCNPGPMTLQGTNTYLVGTGPRRILIDTGEPAIPEYISCLKQALTEFNTAIQEIVVTHWHRDHSGGIGDICKSINNDTTYCIKKLPRNPQREEIIGNGEQQYVYLKDGDVIKTEGATLRVLYTPGHTDDHMALLLEEENAIFSGDCILGEGTTVFEDLYDYMNSLKELLKIKADIIYPGHGPVIHNAEAKIQQYISHRNIREQQILTLFRENFEKSFTVMELVKIIYKNTPENLHEMAKHNLLLHLKKLEKEGKIFSNTDPDKKWKAHL

Approximately 56.0 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.