MC4R 蛋白, Mouse (Cell-Free, His)

MC4R is a receptor for adrenocorticotropic hormone and α, β, and γ-MSH and plays a key role in regulating energy homeostasis and somatic cell growth. Mediated by G proteins, it forms disulfide-linked homodimers and higher-order oligomers. MC4R Protein, Mouse (Cell-Free, His) is the recombinant mouse-derived MC4R protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of MC4R Protein, Mouse (Cell-Free, His) is 332 a.a., with molecular weight of 43.0 kDa.

MC4R 是促肾上腺皮质激素和 α-、β- 和 γ-MSH 共有的七肽核心特异受体，在调节能量稳态和体细胞生长中发挥着关键作用。在刺激腺苷酸环化酶产生 cAMP 的 G 蛋白介导下，该受体形成二硫键连接的同二聚体，并可以进一步组装成更高阶的寡聚体。MC4R 与 ATRNL1 相互作用，并与 MGRN1 相互作用，通过与 GNAS 结合竞争来抑制激动剂诱导的 cAMP 产生。此外，它与 MRAP 和 MRAP2 形成复合物，增强配体敏感性和 cAMP 生成，从而有助于其多方面的调节功能。

Mouse

E. coli Cell-free

N-10*His

P56450 (M1-Y332)

17202

MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY

43.0 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.