MMP-7 蛋白, Rat (P. pastoris, His)

The MMP-7 protein is an enzyme with multifunctional substrate-degrading capabilities, acting on casein, gelatin (types I, III, IV, and V) and fibronectin. As a multifunctional matrix metalloproteinase, MMP-7 contributes to tissue remodeling and renewal, including procollagenase activation, demonstrating its role in the regulation of collagen metabolism. MMP-7 Protein, Rat (P. pastoris, His) is the recombinant rat-derived MMP-7 protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of MMP-7 Protein, Rat (P. pastoris, His) is 170 a.a., with molecular weight of 20.9 kDa.

MMP-7 蛋白作为一种酶，能够降解各种底物，包括酪蛋白、I、III、IV 和 V 型明胶以及纤连蛋白。这种多功能基质金属蛋白酶具有蛋白水解活性，有助于组织重塑和周转。此外，MMP-7 在原胶原酶的激活中发挥作用，反映出它参与胶原代谢的调节。MMP-7 的多种底物特异性凸显了其在调节细胞外基质和影响与组织稳态、修复和发育相关的细胞过程中的重要性。

Measured by its ability to cleave 60μM fluorogenic peptide substrate Mca-KPLGL-Dpa-AR-NH2. The specific activity is 223.769 pmol/min/µg, as measured under the described conditions.

Rat

P. pastoris

N-6*His

P50280 (F98-L267)

25335  [NCBI]

FSLMPNSPKWHSRTVTYRIVSYTTDLPRFLVDQIVKRALRMWSMQIPLNFKRVSWGTADIIIGFARGDHGDNFPFDGPGNTLGHAFAPGPGLGGDAHFDKDEYWTDGEDSGVNFLFVATHELGHSLGLGHSSVPSSVMYPTYQGDHSEDFSLTKDDIAGIQKLYGKRNKL

30 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.