MOB1A 蛋白, Human (His)

In the Hippo signaling pathway, MOB1A serves as a vital activator, governing organ size and suppressing tumors by modulating proliferation and apoptosis. Acting in a kinase cascade, MOB1A, along with STK3/MST2 and STK4/MST1, phosphorylates and activates LATS1/2, influencing the YAP1 oncoprotein and WWTR1/TAZ. This orchestrated phosphorylation controls gene expression pivotal for cell processes. Additionally, MOB1A stimulates STK38 and STK38L kinase activity, cooperating with STK3/MST2 and forming intricate interactions with key pathway components, contributing to its complex regulatory network. MOB1A Protein, Human (His) is the recombinant human-derived MOB1A protein, expressed by E. coli, with C-6*His labeled tag. The total length of MOB1A Protein, Human (His) is 215 a.a., with molecular weight of ~29.0 kDa.

MOB1A 是 Hippo 信号通路中的关键激活剂，通过调节增殖和凋亡在调节器官大小和抑制肿瘤方面发挥着至关重要的作用。该通路的核心涉及激酶级联，其中 STK3/MST2 和 STK4/MST1 与调节蛋白 SAV1 复合，磷酸化并激活 LATS1/2 及其调节伙伴 MOB1。随后，MOB1 磷酸化并灭活 YAP1 癌蛋白和 WWTR1/TAZ。YAP1 的磷酸化可防止其易位到细胞核中，从而控制对细胞增殖、死亡和迁移至关重要的基因的表达。MOB1A还刺激STK38和STK38L的激酶活性，与STK3/MST2协同激活STK38。此外，MOB1A 与 STK38、STK38L、LATS1 和 LATS2 形成复杂的相互作用，从而形成 Hippo 信号通路内的复杂调控网络。

Human

E. coli

C-6*His

Q9H8S9 (S2-R216)

55233  [NCBI]

SFLFSSRSSKTFKPKKNIPEGSHQYELLKHAEATLGSGNLRQAVMLPEGEDLNEWIAVNTVDFFNQINMLYGTITEFCTEASCPVMSAGPRYEYHWADGTNIKKPIKCSAPKYIDYLMTWVQDQLDDETLFPSKIGVPFPKNFMSVAKTILKRLFRVYAHIYHQHFDSVMQLQEEAHLNTSFKHFIFFVQEFNLIDRRELAPLQELIEKLGSKDR

Approximately 29.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.