2. 重组蛋白
  3. Viral Proteins
  4. Influenza Viruses Proteins
  5. Influenza Virus Neuraminidase
  6. NA/Neuraminidase 蛋白, H5N1 (ABU94738, sf9, His)

NA/Neuraminidase 蛋白, H5N1 (ABU94738, sf9, His)

目录号: HY-P73758
产品使用指南

神经氨酸酶 (NA) 被描述为一种受体破坏酶，因为它会从细胞受体上裂解末端唾液酸。NA 借此促进病毒侵入上呼吸道、在病毒出芽过程中促进病毒释放、阻止了自聚集、确保了子代病毒在细胞间的有效传播并在宿主范围限制复制和毒力中起作用。NA/Neuraminidase 蛋白, H5N1 (ABU94738, sf9, His) 是重组的 NA/神经氨酸酶蛋白，由 Sf9 insect cells 表达，带有 C-His 标签。NA/Neuraminidase 蛋白, H5N1 (ABU94738, sf9, His) 全长 414 个氨基酸，分子量约为 ~51.1 kDa。

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描述

Neuraminidase (NA) is described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. Whereby, NA facilitates viral invasion of the upper airways, facilitates virus release during virus budding, prevents self-aggregation and ensures the efficient spread of the progeny virus from cell to cell, and also plays a role in the determination of host range restriction on replication and virulence. NA/Neuraminidase Protein, H5N1 (ABU94738, sf9, His) is the recombinant Virus-derived NA/Neuraminidase protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of NA/Neuraminidase Protein, H5N1 (ABU94738, sf9, His) is 414 a.a., with molecular weight of ~51.1 kDa.
研究背景

神经氨酸酶 (NA) 被描述为一种受体破坏酶，因为它会从细胞受体上裂解末端唾液酸。NA 可能通过裂解气道上皮细胞粘蛋白上的唾液酸来促进病毒侵入上呼吸道。NA 催化从病毒和细胞糖复合物中去除末端唾液酸残基，在病毒出芽过程中裂解糖基化 HA 上的末端唾液酸，以促进病毒释放，并通过进一步去除细胞表面的唾液酸来帮助病毒在循环中传播。这些分裂阻止了自聚集，确保了子代病毒在细胞间的有效传播，否则感染将被限制在一轮复制中。NA 也在宿主范围限制复制和毒力中起作用[1][2]。
种属

Virus
表达系统

Sf9 insect cells
标签

C-His
蛋白编号

ABU94738 (H36-K449)
基因 ID

/
蛋白结构
N-term
H5N1 NA (H36-K449)
Accession # ABU94738
His
C-term
同用名
NA; Neuraminidase; NA/Neuraminidase Protein, H5N1 (A/Anhui/1/2005, sf9, His)
分子量

Approximately 51.1 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

NA/Neuraminidase Protein, H5N1 (ABU94738, sf9, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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