Neuropilin-1 蛋白, Human (Biotinylated, HEK293, His-Avi, solution)

Neuropilin-1 Protein plays a significant role by binding to VEGF-165, potentially inhibiting its cellular binding and inducing apoptosis. This dual functionality suggests its role in regulating VEGF-mediated processes. Interactions with semaphorin family members highlight its versatile ligand-binding capability. Neuropilin-1's expression adversely affects blood vessel number and integrity, suggesting a potential role in angiogenesis. Its diverse interactions underscore its importance in orchestrating complex cellular processes and implications in angiogenesis and apoptotic pathways. Neuropilin-1 Protein, Human (Biotinylated, HEK293, His-Avi, solution) is the recombinant human-derived Neuropilin-1 protein, expressed by HEK293 , with C-Avi, C-His labeled tag and V179A mutation. The total length of Neuropilin-1 Protein, Human (Biotinylated, HEK293, His-Avi, solution) is 623 a.a., with molecular weight of ~73.1 kDa.

Neuropilin-1 蛋白在与 VEGF-165 结合时发挥着重要作用，可能抑制其与细胞的结合，并通过隔离 VEGF-165 诱导细胞凋亡。这种双重功能表明 Neuropilin-1 参与 VEGF 介导的细胞过程的调节。此外，Neuropilin-1 可能与信号蛋白家族的各个成员相互作用，表明它在与不同配体结合方面具有多功能性。值得注意的是，它的表达似乎对血管数量和完整性产生不利影响，表明其在血管生成和血管发育中具有潜在作用。 Neuropilin-1 的多种相互作用和调节作用强调了它在协调复杂细胞过程中的重要性及其在血管生成和细胞凋亡途径中的潜在影响。

Measured by its binding ability in a functional ELISA. Immobilized VEGF165 at 2 μg/mL (100 μL/well) can bind Biotinylated Neuropilin-1 Protein, Human (644a.a, HEK293, His-Avi) and the EC₅₀ is 197.1 ng/mL.

Human

HEK293

C-Avi;C-His

O14786-2 (F22-K644, V179A)

8829  [NCBI]

Approximately 73.1 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.