Otolin-1 蛋白, Human (HEK293, His)

Otolin-1 is a collagen-like protein that shows specific expression in the inner ear, where it is a key component that provides the organic scaffolding for the otic bulb (the calcium carbonate structure found in the otic bulb and utricle). Otolin-1 plays a key role as a scaffold in the biomineralization process by chelating calcium and forming interconnected fibrils between otoliths, thereby integrating into the calcium crystal structure. Otolin-1 Protein, Human (HEK293, His) is the recombinant human-derived Otolin-1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Otolin-1 Protein, Human (HEK293, His) is 454 a.a., with molecular weight of 84-94 kDa.

Otolin-1 是一种在内耳中特异性表达的胶原蛋白样蛋白，是耳石形成的关键成分，耳石是位于耳朵球囊和椭圆囊中的重要碳酸钙结构。这种蛋白质充当有机支架，通过隔离钙并在耳石之间形成互连原纤维来促进生物矿化。Otolin-1 与钙晶体结构的结合进一步凸显了它对这一过程的参与。与 OC90 一起，Otolin-1 在调节方解石晶体形态和生长动力学方面发挥着作用。该蛋白质以同源寡聚物形式存在，可能通过二硫键形成同源三聚体。此外，Otolin-1 与 OC90 和 CBLN1 相互作用，强调其复杂地参与对内耳功能至关重要的分子相互作用。（参考：提供的资料）

Human

HEK293

C-6*His

A6NHN0 (K24-P477)

131149  [NCBI]

KTTPHTKFTKKSEEREMPKGLKPSSGPPPEEEETLFTEMAEMAEPITKPSALDSVFGTATLSPFENFTLDPADFFLNCCDCCSPVPGQKGEPGETGQPGPKGEAGNLGIPGPPGVVGPQGPRGYKGEKGLKGERGDQGVPGYPGKPGAQGEPGPKGDKGNIGLGGVKGQKGSKGDTCGNCTKGEKGDQGAMGSPGLHGGPGAKGEKGEMGEKGEMGDKGCCGDSGERGGKGQKGEGGMKGEKGSKGDSGMEGKSGRNGLPGAKGDPGIKGEKGELGPPGLLGPTGPKGDIGNKGVRGPTGKKGSRGFKGSKGELARVPRSAFSAGLSKPFPPPNIPIKFEKILYNDQGNYSPVTGKFNCSIPGTYVFSYHITVRGRPARISLVAQNKKQFKSRETLYGQEIDQASLLVILKLSAGDQVWLEVSKDWNGVYVSAEDDSIFTGFLLYPEETSGISP

84-94 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.