PARL 蛋白, Human (Cell-Free, Myc)

PARL proteins play a critical role in regulating apoptosis during postnatal growth. It is essential for processing the anti-apoptotic form of OPA1, preventing mitochondrial cytochrome c release in response to intrinsic apoptotic signals. PARL Protein, Human (Cell-Free, Myc) is the recombinant human-derived PARL protein, expressed by E. coli Cell-free , with C-Myc labeled tag. The total length of PARL Protein, Human (Cell-Free, Myc) is 327 a.a., with molecular weight of 37.8 kDa.

PARL 在细胞过程的复杂协调中发挥着关键作用，特别是在出生后生长过程中细胞凋亡的控制中。其重要作用在于 OPA1 抗凋亡形式的蛋白水解过程，防止线粒体细胞色素 c 响应内在凋亡信号而释放。此外，PARL 对于 PINK1 的成熟是不可或缺的，有助于其在被线粒体加工肽酶 (MPP) 切割后转化为 52kDa 成熟形式。值得注意的是，PARL 通过介导受损线粒体中丝氨酸/苏氨酸蛋白磷酸酶 PGAM5 的裂解，对线粒体膜电位的损失做出动态响应，表现出多功能性。此外，PARL 有助于 CLPB、DIABLO/SMAC、STARD7 和 TTC19 的处理，揭示了其在塑造线粒体功能和形态方面的多方面参与，对细胞凋亡活性和细胞健康具有影响。

Human

E. coli Cell-free

C-Myc

Q9H300 (F53-K379)

55486

FRKAPRKVEPRRSDPGTSGEAYKRSALIPPVEETVFYPSPYPIRSLIKPLFFTVGFTGCAFGSAAIWQYESLKSRVQSYFDGIKADWLDSIRPQKEGDFRKEINKWWNNLSDGQRTVTGIIAANVLVFCLWRVPSLQRTMIRYFTSNPASKVLCSPMLLSTFSHFSLFHMAANMYVLWSFSSSIVNILGQEQFMAVYLSAGVISNFVSYVGKVATGRYGPSLGASGAIMTVLAAVCTKIPEGRLAIIFLPMFTFTAGNALKAIIAMDTAGMILGWKFFDHAAHLGGALFGIWYVTYGHELIWKNREPLVKIWHEIRTNGPKKGGGSK

37.8 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.