Periostin/OSF-2 蛋白, Rat (HEK293, His)

Periostin/OSF-2 Protein, a multifaceted regulator, induces cell attachment and spreading, participates in cell adhesion, and enhances BMP1 incorporation into the fibronectin matrix. It forms a structural homodimer and interacts with BMP1 and fibronectin. This interplay positions Periostin as a key player in regulating cellular and tissue functions, including cell adhesion, tissue architecture, and extracellular matrix modulation. Periostin/OSF-2 Protein, Rat (HEK293, His) is the recombinant rat-derived Periostin/OSF-2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Periostin/OSF-2 Protein, Rat (HEK293, His) is 777 a.a., with molecular weight of approximately 95 kDa.

骨膜素蛋白是一种多功能分子，通过诱导细胞附着和扩散在细胞过程中发挥关键作用，证明了其在细胞粘附动力学中的重要性。此外，Periostin 通过增强 BMP1 与纤连蛋白基质的结合，促进赖氨酰氧化酶 LOX 的随后蛋白水解激活，从而有助于结缔组织的结构完整性。在结构上，Periostin 以同二聚体形式存在，在功能上，它与 BMP1 和纤连蛋白等关键伙伴相互作用。这种复杂的相互作用网络强调了 Periostin 在介导细胞粘附和促进结缔组织细胞外基质结构方面的多种功能，强调了其在维持组织完整性和功能方面的重要作用^[1][2]。

Measured by its ability to induce adhesion of ATDC5 mouse chondrogenic cells. The ED₅₀ for this effect is 44.48 ng/mL, corresponding to a specific activity is 2.248×10⁴ units/mg.

Rat

HEK293

C-6*His

D3ZAF5 (N24-S800)

361945  [NCBI]

NSYYDKVLAHSRIRGRDQGPNVCALQQILGTKKKYFSSCKNWYQGAICGKKTTVLYECCPGYMRMEGMKGCPAVMPIDHVYGTLGIVGATTTQHYSDVSKLREEIEGKGSYTYFAPSNEAWDNLDSDIRRGLENNVNVELLNALHSHMVNKRMLTKDLKHGMVIPSMYNNLGLFINHYPNGVVTVNCARVIHGNQIATNGVVHVIDRVLTQIGTSIQDFIEAEDELSSFRAAAITSDLLESLGRDGHFTLFAPTNEAFEKLPRGVLERIMGDKVASEALMKYHILNTLQCSEAITGGAVFETMEGNTIEIGCEGDSISINGIKMVNKKDIVTKNGVIHLIDEVLIPDSAKQVIELAGKQQTTFTDLVAQLGLASSLKPDGEYTLLAPVNNAFSDDTLSMDQRLLKLILQNHILKVKVGLSDLYNGQILETIGGKQLRVFVYRTAICIENSCMVRGSKQGRNGAIHIFREIIQPAEKSLHEKLRQDKRFSIFLSLLEAADLKDLLTQPGDWTLFAPTNDAFKGMTNEEREILIGDKNALQNIILYHLTPGVYIGKGFEPGVTNILKTTQGSKIYVKGVNETLLVNELKSKESDIMTTNGVIHVVDKLLYPADIPVGNDQLLELLNKLIKYIQIKFVRGSTFKEIPMTVYTTKIITKLVEPKIKVIQGSLQPIIKTEGPAMTKIHIEGEPDFRLIKEGETVTEVIHGEPVIKKYTKIIDGVPVEITEKETREERIITGPEIKYTRISTGGGETEETLQKFLQKDTPAKKIQANKRVQGS

approximately 95 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 500 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.