PPAR alpha 蛋白, Human (His)

PPAR alpha Protein, human (His), a member of the nuclear receptor family, is a transcription factor that regulates the expression of genes related to lipid metabolism in a ligand-dependent manner.

过氧化物酶体增殖物激活受体 (PPAR) 是配体依赖性转录因子，属于人类核受体超家族，由 48 个成员组成。PPAR 包括三种亚型：PPARα、PPARγ 和 PPARδ。PPARα 通过调节与脂质代谢相关的一组基因的转录来参与脂质稳态，从而降低血液甘油三酯水平。PPARα 作为降血脂药物的靶点而备受关注^[1]。

Human

E. coli

N-6*His

Q07869-1 (D202-Y468)

5465  [NCBI]

DLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY

Approximately 32.5kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.

• [1]. Takuji Oyama, et al. Crystal Structures of the Human Peroxisome Proliferator-Activated Receptor (PPAR)α Ligand-Binding Domain in Complexes with a Series of Phenylpropanoic Acid Derivatives Generated by a Ligand-Exchange Soaking Method. Biol Pharm Bull. 2021;44(9):1202-1209.  [Content Brief]