1. 重组蛋白
  2. Receptor Proteins
  3. PTK7 蛋白, Human (P.pastoris, His)

PTK7 蛋白, Human (P.pastoris, His)

目录号: HY-P71821
COA 产品使用指南

PTK7 蛋白是一种无活性的酪氨酸激酶,在非经典和经典 Wnt 信号通路中发挥关键作用。影响包括细胞粘附、迁移、极性、增殖、肌动蛋白细胞骨架重组和凋亡。PTK7 蛋白, Human (P.pastoris, His) 是重组的 PTK7 蛋白,由 P. pastoris 表达,带有 N-6*His 标签。PTK7 蛋白, Human (P.pastoris, His) 全长 674 个氨基酸,分子量约为 ~76.6 kDa。

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5 μg ¥1480 In-stock
10 μg ¥2520 In-stock
50 μg ¥7060 In-stock
100 μg   询价  

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描述

The PTK7 protein is an inactive tyrosine kinase that plays a key role in both non-canonical and canonical Wnt signaling pathways. Effects include cell adhesion, migration, polarity, proliferation, actin cytoskeleton reorganization, and apoptosis. PTK7 Protein, Human (P.pastoris, His) is the recombinant human-derived PTK7 protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of PTK7 Protein, Human (P.pastoris, His) is 674 a.a., with molecular weight of ~76.6 kDa.

研究背景

PTK7 蛋白是一种无活性的酪氨酸激酶,在 Wnt 信号传导通路中发挥着重要作用,是非经典(Wnt/平面细胞极性信号传导)和经典 Wnt 信号传导通路的组成部分。它涉及多种细胞过程,包括细胞粘附、迁移、极性、增殖、肌动蛋白细胞骨架重组和凋亡。PTK7 还有助于关键的发育事件,例如胚胎发生、上皮组织组织和血管生成。值得注意的是,它与 CTNNB1 相互作用,强调了它参与 Wnt 通路调节及其对细胞功能的影响,在正常和病理情况下具有更广泛的影响。

种属

Human

表达系统

P. pastoris

标签

N-6*His

蛋白编号

Q13308 (A31-T704)

基因 ID
蛋白结构
N-term
6*His
PTK7 (A31-T704)
Accession # Q13308
C-term
同用名
CCK 4; CCK-4; Colon carcinoma kinase 4; Inactive tyrosine-protein kinase 7; Serum response factor; Srf; Tyrosine-protein kinase-like 7
氨基酸序列

AIVFIKQPSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERADGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQT

分子量

Approximately 76.6 kDa

纯度

Greater than 90% as determined by reducing SDS-PAGE.

性状

无菌粉末.

组分

Lyophilized after extensive dialysis against solution in 20 mM Tris-HC1, 0.5 M NaCl, 6% Trehalose, pH 8.0.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料

PTK7 Protein, Human (P.pastoris, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
PTK7 Protein, Human (P.pastoris, His)
目录号:
HY-P71821
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