SECTM1A 蛋白, Mouse (HEK293, His)

SECTM1A Protein is a protein that encoded by SECTM1A gene. SECTM1A can bind to GITR on the surface of macrophages and activate the PI3K–Akt pathway, thereby enhancing the phagocytosis and bactericidal ability of macrophages SECTM1A can inhibit NF-κB signaling by activating the LXRα pathway, therby suppressing the inflammatory response. SECTM1A can positively regulate local proliferation of TRMs in the context of acute inflammation. SECTM1A Protein, Mouse (HEK293, His) is the recombinant mouse-derived SECTM1A protein, expressed by HEK293 , with C-6*His labeled tag. The total length of SECTM1A Protein, Mouse (HEK293, His) is 138 a.a., with molecular weight of 20-40 kDa.

分泌型跨膜蛋白 1A (SECTM1A) 是由 SECTM1A 基因编码的蛋白质。SECTM1A可以与巨噬细胞表面的 GITR 结合并激活 PI3K-Akt 通路，从而增强巨噬细胞的吞噬和杀菌能力，改善脓毒症小鼠的生存结果。SECTM1A 作为替代 CD7 配体，也能够充当 T 细胞共刺激剂，增强 T 细胞增殖和 IL-2 产生，但这种作用依赖于糖皮质激素诱导的 TNFR (GITR) 激活。SECTM1A 作为一种新的 GITR 配体，促进 Th 细胞特别是 Th 2细胞的扩增，增加 Th2 细胞因子的分泌，从而刺激 TRM 的局部增殖，提高 LPS 注射后动物的存活率。SECTM1A 可以通过激活 LXRα 通路来抑制 NF-κB 信号传导，从而抑制炎症反应。SECTM1A 可用于炎症性疾病的研究^[1][2][3]。

Mouse

HEK293

C-6*His

A2ABP9 (Q28­T165)

209588  [NCBI]

QNKSWDNPICTEGILSVPRGNPAVMTCNISNTFTDVTIQLSANGKDKTIFDKKPQGNFSWRGWELQVQGGLAQLVIKDTQDDHTGIYLWQLHGRQRCYKNITLNILEPSNEDKVPDTTLFTSFPDHAKSSPIEGKPGT

20-40 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.