Serpin A8/Angiotensinogen 蛋白, Human (HEK293, His)

Serpin A8/angiotensinogen protein is an important component of the renin-angiotensin system (RAS), which regulates blood pressure, fluid balance, and electrolyte homeostasis. Serpin A8/Angiotensinogen Protein, Human (HEK293, His) is the recombinant human-derived Serpin A8/Angiotensinogen protein, expressed by HEK293 , with C-His labeled tag. The total length of Serpin A8/Angiotensinogen Protein, Human (HEK293, His) is 452 a.a., with molecular weight of 52-64 kDa.

Serpin A8，也称为血管紧张素原，是肾素-血管紧张素系统 (RAS) 中不可或缺的元素，肾素-血管紧张素系统是控制血压、体液和电解质稳态的有效调节框架。它直接作用于血管平滑肌，产生强大的血管收缩影响，并通过与交感神经系统的相互作用动态影响心肌收缩力和心率。此外，血管紧张素原在塑造肾脏钠和水的吸收方面发挥着关键作用，通过刺激肾上腺皮质中的肾小球带细胞合成和释放醛固酮来发挥其作用。这种多方面的功能是通过血管紧张素原与血管紧张素受体 AGTR1 和 AGTR2 的结合介导的，从而协调一系列的生理反应。除了在 RAS 中的关键作用之外，血管紧张素原还表现出与 DEAR/FBXW7-AS1 受体结合的能力，扩大了其分子相互作用的范围，并对其调节影响提出了更广泛的影响。

Measured in a cell proliferation assay using HT-29 human coloncancer cells. The ED₅₀ for this effect is 160.2 ng/mL, corresponding to a specificactivity is 6242.19 Unit/mg.

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  Measured in a cell proliferation assay using HT-29 human coloncancer cells.The ED₅₀ for this effect is 160.2 ng/mL, corresponding to a specificactivity is 6242.19 unit/mg.

Human

HEK293

C-His

P01019 (D34-A485)

183  [NCBI]

DRVYIHPFHLVIHNESTCEQLAKANAGKPKDPTFIPAPIQAKTSPVDEKALQDQLVLVAAKLDTEDKLRAAMVGMLANFLGFRIYGMHSELWGVVHGATVLSPTAVFGTLASLYLGALDHTADRLQAILGVPWKDKNCTSRLDAHKVLSALQAVQGLLVAQGRADSQAQLLLSTVVGVFTAPGLHLKQPFVQGLALYTPVVLPRSLDFTELDVAAEKIDRFMQAVTGWKTGCSLMGASVDSTLAFNTYVHFQGKMKGFSLLAEPQEFWVDNSTSVSVPMLSGMGTFQHWSDIQDNFSVTQVPFTESACLLLIQPHYASDLDKVEGLTFQQNSLNWMKKLSPRTIHLTMPQLVLQGSYDLQDLLAQAELPAILHTELNLQKLSNDRIRVGEVLNSIFFELEADEREPTESTQQLNKPEVLEVTLNRPFLFAVYDQSATALHFLGRVANPLSTA

52-64 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.