Serum Albumin/ALB 蛋白, Rabbit (HEK293, His)

ALB Protein is a serum protein synthesized by the liver that plays a crucial role in maintaining fluid balance and transporting various molecules in the bloodstream. It is involved in the regulation of osmotic pressure and acts as a carrier for hormones, fatty acids, and drugs. Dysregulation of ALB Protein has been associated with various diseases, including liver disease and kidney disease. Targeting ALB Protein may offer potential therapeutic interventions in these conditions by restoring fluid balance, improving transport functions, and supporting liver and kidney function. Serum Albumin/ALB Protein, Rabbit (HEK293, His) is the recombinant Rabbit-derived Serum Albumin/ALB protein, expressed by HEK293, with C-His labeled tag. The total length of Serum Albumin/ALB Protein, Rabbit (HEK293, His) is 584 a.a., with molecular weight of 60-70 kDa.

ALB 蛋白是一种多功能分子，可结合水、Ca(2+)、Na(+)、K(+)、脂肪酸、激素、胆红素和药物。其主要作用是调节血液的胶体渗透压。作为血浆中的主要锌转运蛋白，它结合约 80% 的血浆锌，同时也作为主要的钙和镁转运蛋白，结合血浆中约 45% 的循环钙和镁。ALB 蛋白可能具有多个钙结合位点，并且可能以非特异性方式结合钙。残基 Asp-273 处锌和钙之间的相互作用表明血液中锌和钙转运之间存在串扰。其亲和力顺序为锌>钙>镁。此外，ALB 蛋白与细菌铁载体肠杆菌素相互作用，抑制其铁吸收，并可能限制大肠杆菌等肠道细菌的生长。值得注意的是，它不会阻碍细菌铁载体需氧菌素对铁的吸收。ALB 蛋白还通过与 FCGRT 相互作用在 ALB 稳态中发挥作用，并且还与 TASOR 相互作用。在血浆中，ALB 蛋白与发色团结合的 α-1-微球蛋白形成共价连接的复合物，而不会阻碍脂肪酸与 ALB 的结合。

Rabbit

HEK293

C-His

P49065-1 (E25-G608)

100009195  [NCBI]

60-70 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized a 0.22 μm filtered solution of PBS, pH 7.4. Normally trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.