SIRT5 蛋白, Human (Flag)

SIRT5 Proteins, belonging to the sirtuin family, possess a sirtuin core domain and share homology with yeast Sir2 protein. They are classified in class III of the sirtuin family and undergo alternative splicing, resulting in multiple transcript variants. Their ubiquitous expression in tissues like the heart, liver, and 25 others suggests their involvement in diverse cellular processes. SIRT5 Protein, Human (Flag) is the recombinant human-derived SIRT5 protein, expressed by E. coli , with N-Flag labeled tag. The total length of SIRT5 Protein, Human (Flag) is 309 a.a., with molecular weight of ~33-37 kDa.

SIRT5 是 Sirtuin 家族的成员，与酵母 Sir2 蛋白具有同源性，并具有 Sirtuin 核心结构域。Sirtuin 家族分为四类，虽然人类 Sirtuin 的具体功能尚未完全阐明，但酵母 Sirtuin 蛋白已知可调节表观遗传基因沉默并抑制 rDNA 重组。研究表明，人沉默调节蛋白可能作为具有单 ADP-核糖基转移酶活性的细胞内调节蛋白。SIRT5 属于沉默调节蛋白家族的 III 类，它会经历选择性剪接，从而产生多种转录变体。SIRT5 的表达无处不在，可在多种组织中观察到，包括心脏、肝脏和 25 种其他组织，这凸显了它可能参与多种细胞过程。

Human

E. coli

N-Flag

NP_036373.1 (R2-S310)

23408  [NCBI]

RPLQIVPSRLISQLYCGLKPPASTRNQICLKMARPSSSMADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPICPALSGKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPATNRFRFHFQGPCGTTLPEALACHENETVS

Approximately 33-37 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.