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  3. SLC16A2 蛋白, Human (Sf9, His, MBP, FLAG)

SLC16A2 蛋白, Human (Sf9, His, MBP, FLAG)

目录号: HY-P702021
产品使用指南

SLC16A2 蛋白是一种特定的甲状腺激素跨膜转运蛋白,可促进甲状腺激素跨细胞膜的双向运动,与 pH 或 Na(+) 梯度无关。SLC16A2 对 T3 和 T4 等底物具有显着的偏好,是甲状腺激素转运的关键介质。SLC16A2 蛋白, Human (Sf9, His, MBP, FLAG) 是重组的 SLC16A2 蛋白,由 Sf9 insect cells 表达,带有 N-MBP, C-Flag, N-8*His 标签。SLC16A2 蛋白, Human (Sf9, His, MBP, FLAG) 全长 538 个氨基酸。

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描述

The SLC16A2 protein is a specific thyroid hormone transmembrane transporter that promotes bidirectional movement of thyroid hormone across cell membranes independent of pH or Na(+) gradients. SLC16A2 has a significant preference for substrates such as T3 and T4 and is a key mediator of thyroid hormone transport. SLC16A2 Protein, Human (Sf9, His, MBP, FLAG) is the recombinant human-derived SLC16A2 protein, expressed by Sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag. The total length of SLC16A2 Protein, Human (Sf9, His, MBP, FLAG) is 538 a.a., .

研究背景

SLC16A2 是一种特定的甲状腺激素跨膜转运蛋白,在促进甲状腺激素跨细胞膜的摄取和流出方面发挥着关键作用,其运行独立于 pH 或 Na(+) 梯度。由于对碘甲状腺原氨酸 T3 和 T4 等底物的显着偏好,以及较小程度的 rT3 和 3,3-二碘甲状腺原氨酸 (3,3'-T2),SLC16A2 成为甲状腺激素转运的关键介质。它的重要性在 T3 的运输中尤其明显,特别是通过血脑屏障,强调了它在甲状腺激素进入大脑方面的关键作用。转运蛋白转运甲状腺激素的能力强调了其在调节这些必需分子的细胞可用性方面的重要性,强调了其对甲状腺激素稳态的影响及其在各种生理环境中的潜在治疗相关性。

种属

Human

表达系统

Sf9 insect cells

标签

N-MBP;C-Flag;N-8*His

蛋白编号

P36021 (A2-I539)

基因 ID

6567

蛋白结构
N-term
8*His-MBP
SLC16A2 (A2-I539)
Accession # P36021
Flag
C-term
同用名
SLC16A2; Monocarboxylate transporter 8; MCT 8; Monocarboxylate transporter 7; MCT 7; Solute carrier family 16 member 2; X-linked PEST-containing transporter
纯度

Greater than 90% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

SLC16A2 Protein, Human (Sf9, His, MBP, FLAG) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
SLC16A2 Protein, Human (Sf9, His, MBP, FLAG)
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HY-P702021
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